Analytical Data
-
Gene name
UQCRC1
- Application
-
Alternative Names
UQCRC1；Cytochrome b-c1 complex subunit 1. mitochondrial
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P31930
-
Expression Region
35-480aa
-
AA Sequence
TATFAQ ALQFVPETQV SLLDNGLRVA SEQSSQPTCT VGVWIDVGSR FETEKNNGAG YFLEHLAFKG TKNRPGSALE KEVESMGAHL NAYSTREHTA YYIKALSKDL PKAVELLGDI VQNCSLEDSQ IEKERDVILR EMQENDASMR DVVFNYLHAT AFQGTPLAQA VEGPSENVRK LSRADLTEYL STHYKAPRMV LAAAGGVEHQ QLLDLAQKHL GGIPWTYAED AVPTLTPCRF TGSEIRHRDD ALPFAHVAIA VEGPGWASPD NVALQVANAI IGHYDCTYGG GVHLSSPLAS GAVANKLCQS FQTFSICYAE TGLLGAHFVC DRMKIDDMMF VLQGQWMRLC TSATESEVAR GKNILRNALV SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIAEVDASV VREICSKYIY DQCPAVAGYG PIEQLPDYNR IRSGMFWLRF
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UQCRC1, or Ubiquinol-cytochrome c reductase core component 1, is a vital protein in the mitochondrial electron transport chain, specifically as part of Complex III. This multi-subunit enzyme facilitates the transfer of electrons from ubiquinol to cytochrome c, playing a crucial role in cellular respiration and ATP production. Research into UQCRC1 is significant due to its involvement in energy metabolism and its potential link to various metabolic disorders and mitochondrial diseases. Mutations or dysfunction in UQCRC1 can lead to impaired mitochondrial function, contributing to conditions such as cardiomyopathy, neurodegenerative diseases, and aging-related ailments. Recent studies have focused on the structural and functional characterization of UQCRC1, utilizing techniques like cryo-electron microscopy and X-ray crystallography. Understanding the precise mechanisms of UQCRC1 may provide insights into therapeutic targets for mitochondrial dysfunctions. Moreover, the exploration of its interactions with other mitochondrial proteins is vital for understanding its full biological role and implications in health and disease. Therefore, UQCRC1 represents an important area of research within mitochondrial biology, with potential implications for the development of novel strategies to combat diseases associated with mitochondrial dysfunction.
