Analytical Data
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基因名
PDYN
- Application
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别名
ADCA; Alpha neoendorphin; Beta neoendorphin; Beta-neoendorphin-dynorphin; Big Dyn; Big dynorphin; Dyn; Dyn-A17; Dyn-B; Dynorphin A; Dynorphin A(1-13); Dynorphin A(1-17); Dynorphin A(1-8); Dynorphin B; Dynorphin B(1-13); Dynorphin B-29; Enkephalin B; Leu enkephalin; Leumorphin; Neoendorphin dynorphin enkephalin prepropeptide; PDYN; PDYN_HUMAN; PENKB; Preprodynorphin; Preproenkephalin B; Prodynorphin; Proenkephalin B; Rimorphin; SCA23
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01213
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表达区间
1-254 aa
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氨基酸序列
MAWQGLVLAACLLMFPSTTADCLSRCSLCAVKTQDGPKPINPLICSLQCQAALLPSEEWERCQSFLSFFTPSTLGLNDKEDLGSKSVGEGPYSELAKLSGSFLKELEKSKFLPSISTKENTLSKSLEEKLRGLSDGFREGAESELMRDAQLNDGAMETGTLYLAEEDPKEQVKRYGGFLRKYPKRSSEVAGEGDGDSMGHEDLYKRYGGFLRRIRPKLKWDNQKRYGGFLRRQFKVVTRSQEDPNAYSGELFDA
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分子量
54.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on pro-dynorphin (PDYN) recombinant proteins has gained significant attention due to their potential roles in various physiological and pathological processes. PDYN is a precursor protein that is enzymatically cleaved to produce dynorphins, which are a class of endogenous opioid peptides. These peptides have been implicated in modulating pain, stress responses, mood regulation, and addiction. The dysregulation of PDYN and its derived peptides has been associated with several neuropsychiatric disorders, including depression, anxiety, and substance use disorders. Understanding the structure and function of PDYN and its derivatives through recombinant protein techniques enables researchers to investigate their mechanisms of action and interactions with opioid receptors. Such studies are crucial for developing novel therapeutic strategies targeting these pathways, as traditional opioid treatments often lead to tolerance and addiction issues. Recombinant PDYN proteins can serve as valuable tools in drug discovery, allowing for the identification of new compounds that could selectively modulate dynorphin signaling. Additionally, there is growing interest in exploring the role of PDYN in neuroinflammatory processes and neurodegeneration, making it an important target for research in both neuroscience and therapeutic development. Overall, the studies on PDYN recombinant proteins represent a promising frontier in understanding opioid biology and its implications for health and disease.
