Analytical Data
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Gene name
PCYT1A
- Application
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Alternative Names
PCYT1A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49585
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Expression Region
1-367 aa
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AA Sequence
MDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTRERSPSPSFRWPFSGKTSPPCSPANLSRHKAAAYDISEDEED
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Molecular Weight
48.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCYT1A, or Phosphatidylserine Synthase 1, is a crucial enzyme involved in the synthesis of phosphatidylethanolamine and phosphatidylcholine, which are essential phospholipids that play significant roles in cellular membrane integrity and signaling. Abnormalities in PCYT1A function have been implicated in various metabolic disorders, including neurodegenerative diseases, where altered lipid metabolism may contribute to pathology. Recent studies have highlighted the importance of PCYT1A in regulating cell proliferation, apoptosis, and membrane trafficking, making it a potential target for therapeutic interventions. The recombinant production of the PCYT1A protein allows researchers to investigate its biochemical properties, structure-function relationships, and interaction with small molecules or biological substrates. This has critical implications for understanding the enzyme's role in lipid metabolism and its contribution to disease mechanisms. Furthermore, studying PCYT1A through recombinant protein research can facilitate drug design efforts aimed at modulating its activity, potentially leading to novel treatments for conditions associated with lipid dysregulation. As such, the exploration of PCYT1A offers valuable insights into fundamental biological processes and holds promise for its applications in biomedical research and therapeutic development.
