Analytical Data
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Gene name
ARNTL2
- Application
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Alternative Names
CLIF; Class E basic helix-loop-helix Protein 6; bHLHe6; Member of PAS Protein 9
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WYA1
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Expression Region
1-636aa
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AA Sequence
MAAEEEAAAG GKVLREENQC IAPVVSSRVS PGTRPTAMGS FSSHMTEFPR KRKGSDSDPS QSGIMTEKVV EKLSQNPLTY LLSTRIEISA SSGSRVEDGE HQVKMKAFRE AHSQTEKRRR DKMNNLIEEL SAMIPQCNPM ARKLDKLTVL RMAVQHLRSL KGLTNSYVGS NYRPSFLQDN ELRHLILKTA EGFLFVVGCE RGKILFVSKS VSKILNYDQA SLTGQSLFDF LHPKDVAKVK EQLSSFDISP REKLIDAKTG LQVHSNLHAG RTRVYSGSRR SFFCRIKSCK ISVKEEHGCL PNSKKKEHRK FYTIHCTGYL RSWPPNIVGM EEERNSKKDN SNFTCLVAIG RLQPYIVPQN SGEINVKPTE FITRFAVNGK FVYVDQRATA ILGYLPQELL GTSCYEYFHQ DDHNNLTDKH KAVLQSKEKI LTDSYKFRAK DGSFVTLKSQ WFSFTNPWTK ELEYIVSVNT LVLGHSEPGE ASFLPCSSQS SEESSRQSCM SVPGMSTGTV LGAGSIGTDI ANEILDLQRL QSSSYLDDSS PTGLMKDTHT VNCRSMSNKE LFPPSPSEMG ELEATRQNQS TVAVHSHEPL LSDGAQLDFD ALCDNDDTAM AAFMNYLEAE GGLGDPGDFS DIQWTL
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Molecular Weight
70 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ARNTL2, also known as BMAL2, is a member of the bHLH-PAS family of transcription factors and plays a critical role in regulating circadian rhythms and various physiological processes. Research into ARNTL2 has gained momentum due to its potential implications in metabolic disorders, sleep regulation, and overall health. Unlike its well-studied counterpart BMAL1, which is a central component of the core circadian clock, ARNTL2 has been less thoroughly explored, prompting investigations into its function, expression patterns, and possible interactions with other clock genes. Recent studies suggest that ARNTL2 might have distinct roles in modulating circadian gene expression and influencing biological pathways linked to metabolism, particularly in peripheral tissues. Understanding the molecular mechanisms of ARNTL2 can provide insights into its contribution to circadian biology and its potential as a therapeutic target for conditions such as obesity, diabetes, and sleep disorders. Furthermore, the reconstitution of ARNTL2 as a recombinant protein enables researchers to perform detailed biochemical assays to elucidate its functional properties and interactions at the molecular level. Consequently, the study of ARNTL2 is not only vital for expanding our knowledge of circadian regulation but also holds promise for developing novel strategies to combat metabolic and sleep-related diseases. As research progresses, the characterization of ARNTL2 and its roles within the circadian system may reveal critical insights into how circadian disruption can affect health and disease.
