Analytical Data
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基因名
PCGF3
- Application
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别名
DONG1; PCGF3; PCGF3_HUMAN; Polycomb group ring finger 3; Polycomb group RING finger protein 3; Ring finger protein 3; RING finger protein 3A; RNF3A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q3KNV8
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表达区间
1-242 aa
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氨基酸序列
MLTRKIKLWD INAHITCRLC SGYLIDATTV TECLHTFCRS CLVKYLEENN TCPTCRIVIH QSHPLQYIGH DRTMQDIVYK LVPGLQEAEM RKQREFYHKL GMEVPGDIKG ETCSAKQHLD SHRNGETKAD DSSNKEAAEE KPEEDNDYHR SDEQVSICLE CNSSKLRGLK RKWIRCSAQA TVLHLKKFIA KKLNLSSFNE LDILCNEEIL GKDHTLKFVV VTRWRFKKAP LLLHYRPKMD LL
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分子量
28.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCGF3 (Polycomb Group Ring Finger Protein 3) is a member of the Polycomb group (PCG) proteins, which play critical roles in the regulation of gene expression and maintenance of cellular identity through epigenetic mechanisms. Research on PCGF3 has gained traction due to its involvement in various biological processes, including stem cell maintenance, development, and cancer biology. PCGF3 functions primarily as an E3 ubiquitin ligase, modulating protein stability and chromatin organization, which are essential for transcriptional repression. Recent studies have revealed that PCGF3 may also interact with other Polycomb group proteins, contributing to the formation of multi-protein complexes that enable coordinated gene silencing. Dysregulation of PCGF3 has been linked to several malignancies, underscoring its potential as a therapeutic target. As a result, understanding the molecular mechanisms underlying PCGF3's function could provide valuable insights into its role in normal physiology and disease states. Advances in recombinant protein technology enable the production and study of PCGF3 in vitro, facilitating its use in biochemical assays and functional studies to unravel its complex interactions and regulatory networks. Continued investigation into PCGF3 may not only illuminate its specific contributions to cellular processes but also pave the way for novel strategies in cancer treatment and regenerative medicine.
