Analytical Data
-
Gene name
ARMS2
- Application
-
Alternative Names
ARMS2Age-related maculopathy susceptibility Protein 2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P0C7Q2
-
Expression Region
1-107aa
-
AA Sequence
MLRLYPGPMV TEAEGKGGPE MASLSSSVVP VSFISTLRES VLDPGVGGEG ASDKQRSKLS LSHSMIPAAK IHTELCLPAF FSPAGTQRRF QQPQHHLTLS IIHTAAR
-
Molecular Weight
11.8 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The research on ARMS2 (Age-Related Maculopathy Susceptibility 2) recombinant protein has gained significant attention due to its association with age-related macular degeneration (AMD), a leading cause of vision loss in the elderly. ARMS2 is a gene located within the complement factor H (CFH) region on chromosome 10 and has been identified as a risk factor for AMD through various genome-wide association studies (GWAS). The protein encoded by ARMS2 is believed to play a crucial role in the regulation of inflammation and the complement cascade, processes that are pivotal in the pathogenesis of AMD. The study of ARMS2 recombinant protein is vital for understanding its function and interaction within the retinal environment, especially how it may influence the activation of the complement system and contribute to the degeneration of retinal pigment epithelium (RPE) cells. Recombinant forms of ARMS2 can be utilized to explore its molecular mechanisms, structural characteristics, and potential as a therapeutic target. The exploration of ARMS2 holds promise not only for elucidating the biological underpinnings of AMD but also for developing novel strategies to prevent or treat this debilitating condition, ultimately improving outcomes for affected individuals.
