Analytical Data
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Gene name
ARMET
- Application
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Alternative Names
ARP; Manf; MANF_HUMAN; Mesencephalic astrocyte derived neurotrophic factor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55145
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Expression Region
25-182aa
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AA Sequence
LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL
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Molecular Weight
18.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ARMET (activity-regulated member of the ERM family) is a protein that plays a crucial role in the regulation of neuroplasticity and synaptic function. It is predominantly expressed in the brain and has been implicated in various cellular processes, including the modulation of synaptic strength and the facilitation of long-term potentiation, which are essential for learning and memory. Research into ARMET has gained momentum due to its potential involvement in neurodegenerative diseases and psychiatric disorders, where alterations in synaptic plasticity are often observed. Studies have demonstrated that ARMET can be regulated by neuronal activity, suggesting that it acts as a mediating factor in the signaling pathways associated with neuronal responses to external stimuli. Recent investigations have focused on elucidating the molecular mechanisms by which ARMET influences neuronal health and function, including its interactions with other proteins in the signaling cascade. The understanding of ARMET's role could lead to novel therapeutic strategies for addressing cognitive impairments and emotional disorders linked to dysfunctional synaptic plasticity. As the field of neuroscience continues to evolve, further research into ARMET and its regulatory functions offers promising avenues for exploring the complexities of brain function and the underlying mechanisms of neurological diseases.
