Analytical Data
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Gene name
PCGF2
- Application
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Alternative Names
DNA binding protein Mel 18; DNA-binding protein Mel-18; Mel 18; MGC10545; PCGF 2; PCGF2; PCGF2_HUMAN; Polycomb group ring finger 2; Polycomb group RING finger protein 2; RING finger protein 110; RNF110; Zinc finger protein 144; ZNF 144; ZNF144
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35227
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Expression Region
1-344 aa
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AA Sequence
MHRTTRIKIT ELNPHLMCAL CGGYFIDATT IVECLHSFCK TCIVRYLETN KYCPMCDVQV HKTRPLLSIR SDKTLQDIVY KLVPGLFKDE MKRRRDFYAA YPLTEVPNGS NEDRGEVLEQ EKGALSDDEI VSLSIEFYEG ARDRDEKKGP LENGDGDKEK TGVRFLRCPA AMTVMHLAKF LRNKMDVPSK YKVEVLYEDE PLKEYYTLMD IAYIYPWRRN GPLPLKYRVQ PACKRLTLAT VPTPSEGTNT SGASECESVS DKAPSPATLP ATSSSLPSPA TPSHGSPSSH GPPATHPTSP TPPSTASGAT TAANGGSLNC LQTPSSTSRG RKMTVNGAPV PPLT
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Molecular Weight
37.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PCGF2 (Polycomb group RING finger protein 2) is a member of the Polycomb group (PcG) protein family, which plays a critical role in gene silencing and chromatin remodeling. Research indicates that PCGF2 is involved in maintaining stem cell pluripotency and regulating developmental processes. Dysregulation of PCGF2 has been implicated in various cancers, making it a potential target for therapeutic interventions. The study of recombinant PCGF2 protein is essential for understanding its structural and functional properties, as well as its interactions with other proteins and DNA elements. By producing PCGF2 in a recombinant form, researchers can investigate its biochemical activities and elucidate the underlying mechanisms of its role in gene regulation. Furthermore, such studies could pave the way for the development of novel strategies for cancer treatment, as modulation of PCGF2 activity may restore normal gene expression patterns in tumor cells. Overall, the research surrounding PCGF2 recombinant protein not only deepens our understanding of epigenetic regulation but also offers potential insights into therapeutic approaches for diseases associated with aberrant PcG function.
