Analytical Data
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基因名
PCGF1
- Application
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别名
PCGF1; NSPC1; RNF68; Polycomb group RING finger protein 1; Nervous system Polycomb-1; NSPc1; RING finger protein 68
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BSM1
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表达区间
2-259 aa
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氨基酸序列
ASPQGGQIA IAMRLRNQLQ SVYKMDPLRN EEEVRVKIKD LNEHIVCCLC AGYFVDATTI TECLHTFCKS CIVKYLQTSK YCPMCNIKIH ETQPLLNLKL DRVMQDIVYK LVPGLQDSEE KRIREFYQSR GLDRVTQPTG EEPALSNLGL PFSSFDHSKA HYYRYDEQLN LCLERLSSGK DKNKSVLQNK YVRCSVRAEV RHLRRVLCHR LMLNPQHVQL LFDNEVLPDH MTMKQIWLSR WFGKPSPLLL QYSVKEKRR
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分子量
30.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCGF1 (Polycomb Group RING Finger 1) is a member of the Polycomb group (PcG) proteins, which are critical for the regulation of gene expression and chromatin remodeling. Research on PCGF1 has gained significant attention due to its role in maintaining stem cell pluripotency, influencing cell differentiation, and regulating developmental processes. The protein functions primarily as a component of polycomb repressive complexes (PRC), involved in transcriptional repression through histone modifications. Abnormal expression or mutations in PCGF1 have been implicated in various diseases, including cancers, highlighting its potential as a therapeutic target. Moreover, studies have indicated that PCGF1 can interact with other epigenetic regulators, thereby forming complex networks that dictate cellular fates. Understanding the structure and function of recombinant PCGF1 not only provides insights into its biological significance but also assists in deciphering the molecular mechanisms underlying developmental abnormalities and tumorigenesis. Through biochemical assays, structural biology, and functional analyses, researchers aim to elucidate the precise role of PCGF1 in gene regulation and its contributions to cellular homeostasis, paving the way for novel interventions in health and disease management. The recombinant protein derived from cloned PCGF1 can be utilized for functional studies and high-throughput screenings, emphasizing the protein's relevance in both basic and applied research settings.
