Analytical Data
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基因名
PBX3
- Application
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别名
Homeobox protein PBX3; MGC134053 ; OTTHUMP00000064213; Pbx 3; Pbx3; PBX3_HUMAN; Pre B cell leukemia homeobox 3; Pre B cell leukemia transcription factor 3; Pre-B-cell leukemia transcription factor 3; RP11 336P12.1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P40426
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表达区间
1-434 aa
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氨基酸序列
MDDQSRMLQT LAGVNLAGHS VQGGMALPPP PHGHEGADGD GRKQDIGDIL HQIMTITDQS LDEAQAKKHA LNCHRMKPAL FSVLCEIKEK TGLSIRGAQE EDPPDPQLMR LDNMLLAEGV SGPEKGGGSA AAAAAAAASG GSSDNSIEHS DYRAKLTQIR QIYHTELEKY EQACNEFTTH VMNLLREQSR TRPISPKEIE RMVGIIHRKF SSIQMQLKQS TCEAVMILRS RFLDARRKRR NFSKQATEIL NEYFYSHLSN PYPSEEAKEE LAKKCSITVS QVSNWFGNKR IRYKKNIGKF QEEANLYAAK TAVTAAHAVA AAVQNNQTNS PTTPNSGSSG SFNLPNSGDM FMNMQSLNGD SYQGSQVGAN VQSQVDTLRH VINQTGGYSD GLGGNSLYSP HNLNANGGWQ DATTPSSVTS PTEGPGSVHS DTSN
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分子量
47.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PBX3 (Pre-B-cell leukemia homeobox 3) is a member of the PBX family of homeobox transcription factors and plays a pivotal role in various biological processes, including hematopoiesis, organogenesis, and cell differentiation. Abnormalities in PBX3 have been implicated in several hematological malignancies, particularly acute lymphoblastic leukemia (ALL) and myeloid leukemia, where chromosomal rearrangements often lead to the fusion of PBX3 with other oncogenic partners, resulting in the formation of oncogenic fusion proteins. These fusion proteins can alter normal transcriptional regulation, contributing to the transformation of normal cells into malignant ones. The study of PBX3 rearrangements is important not only for understanding the molecular mechanisms underlying leukemia but also for developing targeted therapies. Recent advances in genomic technologies have facilitated the identification and characterization of PBX3 fusions, providing insights into their role in tumorigenesis. Research has shown that PBX3 can interact with various cofactors and signaling pathways, further complicating its role in cancer biology. Furthermore, PBX3 has been suggested as a potential therapeutic target due to its involvement in the proliferation and survival of cancer cells. As a result, ongoing research aims to elucidate the precise functions of PBX3 and its fusion proteins in malignant transformation, with the hope of translating these findings into better diagnostic and therapeutic strategies for leukemia and other related disorders. By understanding the intricate interactions and pathways associated with PBX3, researchers aim to improve clinical outcomes for patients affected by these aggressive hematologic malignancies.
