Analytical Data
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基因名
ARID3B
- Application
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别名
ARI3B_HUMAN; ARID domain containing Protein 3B; ARID domain-containing Protein 3B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IVW6
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表达区间
1-561aa
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氨基酸序列
MEPLQQQQQQ QQQQQKQPHL APLQMDAREK QGQQMREAQF LYAQKLVTQP TLLSATAGRP SGSTPLGPLA RVPPTAAVAQ VFERGNMNSE PEEEDGGLED EDGDDEVAEV AEKETQAASK YFHVQKVARQ DPRVAPMSNL LPAPGLPPHG QQAKEDHTKD ASKASPSVST AGQPNWNLDE QLKQNGGLAW SDDADGGRGR EISRDFAKLY ELDGDPERKE FLDDLFVFMQ KRGTPINRIP IMAKQILDLY MLYKLVTEKG GLVEIINKKI WREITKGLNL PTSITSAAFT LRTQYMKYLY AYECEKKALS SPAELQAAID GNRREGRRPS YSSSLFGYSP AAATAAAAAG APALLSPPKI RFPILGLGSS SGTNTSSPRI SPATTLRKGD GAPVTTVPVP NRLAVPVTLA SQQAGTRTAA LEQLRERLES GEPAEKKASR LSEEEQRLVQ QAFQRNFFSM ARQLPMKIRI NGRAEDRAEA SAAALNLTTS SIGSINMSVD IDGTTYAGVL FAQKPVVHLI TGSAPQSLGS SASSSSSSHC SPSPTSSRGT PSAEPSTSWS L
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分子量
60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ARID3B (AT-rich interactive domain-containing protein 3B) is a member of the ARID family of transcription factors known for their critical roles in regulating gene expression during cell growth, differentiation, and development. Research on ARID3B has garnered attention due to its involvement in various biological processes and potential implications in diseases, particularly cancers and autoimmune disorders. Previous studies have highlighted its role in the regulation of genes associated with immune response and hematopoiesis, indicating its significance in lymphocyte development and function. ARID3B has been shown to act as both a transcriptional activator and repressor, depending on the cellular context and target genes. Furthermore, its dysregulation is linked to oncogenesis, as evidenced by its overexpression in some malignancies, suggesting that ARID3B could serve as a potential biomarker or therapeutic target. To unravel the functional mechanisms of ARID3B, researchers have focused on the characterization of recombinant ARID3B proteins, investigating their biochemical properties, interaction networks, and regulatory roles at the molecular level. This includes studying their binding affinities to specific DNA sequences and interactions with other transcription factors and co-regulators. By understanding the intricate dynamics of ARID3B, scientists aim to elucidate its contributions to cellular processes and disease pathways, paving the way for novel therapeutic strategies that could mitigate the effects of its aberrant activity in disease contexts. Thus, ongoing research into ARID3B recombinant proteins holds promise for advancing our comprehension of its biological significance and potential clinical applications.
