Analytical Data
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基因名
PBX2
- Application
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别名
PBX2; G17; Pre-B-cell leukemia transcription factor 2; Homeobox protein PBX2; Protein G17
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P40425
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表达区间
1-430 aa
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氨基酸序列
MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS GSGDMFLGMP GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR ANGSWQEAVT PSSVTSPTEG PGSVHSDTSN
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分子量
45.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PBX2 (Pre-B-cell leukemia homeobox 2) is a member of the PBX family of transcription factors that play crucial roles in various biological processes, including development, differentiation, and oncogenesis. Research has increasingly focused on PBX2 due to its significant involvement in both normal hematopoiesis and the pathogenesis of certain cancers, particularly in leukemias and solid tumors. Studies have shown that PBX2 interacts with other homeobox proteins and transcription factors, forming complexes that regulate gene expression critical for cell growth and lineage specification. Dysregulation of PBX2 expression or activity has been implicated in malignant transformation, making it a potential target for therapeutic intervention. Moreover, understanding the structural and functional properties of PBX2 and its interactions within cellular contexts can shed light on the molecular mechanisms driving its oncogenic potential. As such, this research not only aims to elucidate the precise role of PBX2 in cancer biology but also seeks to explore innovative strategies for targeting its pathways, ultimately contributing to the development of effective treatment options for patients with PBX2-related malignancies.
