Analytical Data
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Gene name
PBX2
- Application
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Alternative Names
PBX2; G17; Pre-B-cell leukemia transcription factor 2; Homeobox protein PBX2; Protein G17
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P40425
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Expression Region
1-430 aa
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AA Sequence
MDERLLGPPP PGGGRGGLGL VSGEPGGPGE PPGGGDPGGG SGGVPGGRGK QDIGDILQQI MTITDQSLDE AQAKKHALNC HRMKPALFSV LCEIKEKTGL SIRSSQEEEP VDPQLMRLDN MLLAEGVAGP EKGGGSAAAA AAAAASGGGV SPDNSIEHSD YRSKLAQIRH IYHSELEKYE QACNEFTTHV MNLLREQSRT RPVAPKEMER MVSIIHRKFS AIQMQLKQST CEAVMILRSR FLDARRKRRN FSKQATEVLN EYFYSHLSNP YPSEEAKEEL AKKCGITVSQ VSNWFGNKRI RYKKNIGKFQ EEANIYAVKT AVSVTQGGHS RTSSPTPPSS AGSGGSFNLS GSGDMFLGMP GLNGDSYSAS QVESLRHSMG PGGYGDNLGG GQMYSPREMR ANGSWQEAVT PSSVTSPTEG PGSVHSDTSN
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Molecular Weight
45.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PBX2 (Pre-B-cell leukemia homeobox 2) is a member of the PBX family of transcription factors that play crucial roles in various biological processes, including development, differentiation, and oncogenesis. Research has increasingly focused on PBX2 due to its significant involvement in both normal hematopoiesis and the pathogenesis of certain cancers, particularly in leukemias and solid tumors. Studies have shown that PBX2 interacts with other homeobox proteins and transcription factors, forming complexes that regulate gene expression critical for cell growth and lineage specification. Dysregulation of PBX2 expression or activity has been implicated in malignant transformation, making it a potential target for therapeutic intervention. Moreover, understanding the structural and functional properties of PBX2 and its interactions within cellular contexts can shed light on the molecular mechanisms driving its oncogenic potential. As such, this research not only aims to elucidate the precise role of PBX2 in cancer biology but also seeks to explore innovative strategies for targeting its pathways, ultimately contributing to the development of effective treatment options for patients with PBX2-related malignancies.
