Analytical Data
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Gene name
CDC73
- Application
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Alternative Names
CDC73；C1orf28；HRPT2；Parafibromin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6P1J9
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Expression Region
2-531aa
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AA Sequence
ADVLSVLRQ YNIQKKEIVV KGDEVIFGEF SWPKNVKTNY VVWGTGKEGQ PREYYTLDSI LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLGYLNG EASTSASIDR SAPLEIGLQR STQVKRAADE VLAEAKKPRI EDEECVRLDK ERLAARLEGH KEGIVQTEQI RSLSEAMSVE KIAAIKAKIM AKKRSTIKTD LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS TGKNFSKNIF AILQSVKARE EGRAPEQRPA PNAAPVDPTL RTKQPIPAAY NRYDQERFKG KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP PNQKKGSRTP IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE NETLIQRRKD QMQPGGTAIS VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY DEVRLDPNVQ KWDVTVLELS YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F
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Molecular Weight
60.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CDC73, also known as cell division cycle 73, is a critical gene that encodes a protein involved in the regulation of RNA polymerase II transcription and the maintenance of genomic stability. Research on CDC73 has gained prominence due to its association with multiple human diseases, particularly its role as a tumor suppressor in parathyroid carcinoma and familial isolated hyperparathyroidism. The protein plays a pivotal role in the protective mechanisms against cancer by ensuring proper cell cycle regulation and controlling transcriptional programs essential for cell survival and proliferation. Mutations or deletions in the CDC73 gene have been linked to oncogenesis, underscoring the importance of understanding its functional mechanisms. As a result, the production of recombinant CDC73 protein has become a focus for researchers aiming to elucidate the molecular pathways it regulates and its interactions with other cellular components. Utilizing techniques such as molecular cloning and expression systems, scientists can generate large amounts of CDC73 protein for structural and functional analyses. These studies are crucial for the development of potential therapeutic strategies targeting CDC73-related malignancies, thereby advancing our understanding of cancer biology and enhancing therapeutic options for affected patients.
