Analytical Data
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基因名
ORC2L
- Application
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别名
orc2; ORC2_HUMAN; ORC2L; Origin of replication 2 (yeast homolog) like; Origin recognition complex protein 2 homolog; Origin recognition complex subunit 2; Origin recognition complex subunit 2 isoform B; Origin recognition complex subunit 2 like (yeast); Origin recognition complex. subunit 2 homolog; Origin recognition complex. subunit 2. S. cerevisiae. homolog of; Origin recognition complex. subunit 2-like (S. cerevisiae)
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13416
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表达区间
1-577 aa
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氨基酸序列
MSKPELKEDK MLEVHFVGDD DVLNHILDRE GGAKLKKERA QLLVNPKKII KKPEYDLEED DQEVLKDQNY VEIMGRDVQE SLKNGSATGG GNKVYSFQNR KHSEKMAKLA SELAKTPQKS VSFSLKNDPE ITINVPQSSK GHSASDKVQP KNNDKSEFLS TAPRSLRKRL IVPRSHSDSE SEYSASNSED DEGVAQEHEE DTNAVIFSQK IQAQNRVVSA PVGKETPSKR MKRDKTSDLV EEYFEAHSSS KVLTSDRTLQ KLKRAKLDQQ TLRNLLSKVS PSFSAELKQL NQQYEKLFHK WMLQLHLGFN IVLYGLGSKR DLLERFRTTM LQDSIHVVIN GFFPGISVKS VLNSITEEVL DHMGTFRSIL DQLDWIVNKF KEDSSLELFL LIHNLDSQML RGEKSQQIIG QLSSLHNIYL IASIDHLNAP LMWDHAKQSL FNWLWYETTT YSPYTEETSY ENSLLVKQSG SLPLSSLTHV LRSLTPNARG IFRLLIKYQL DNQDNPSYIG LSFQDFYQQC REAFLVNSDL TLRAQLTEFR DHKLIRTKKG TDGVEYLLIP VDNGTLTDFL EKEEEEA
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分子量
65.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ORC2L, a key component of the Origin Recognition Complex (ORC), plays a crucial role in the initiation of DNA replication. Research into ORC2L has gained momentum due to its involvement in cell cycle regulation and its potential implications in cancer biology. As a part of the ORC, which consists of six subunits (Orc1 to Orc6), ORC2L facilitates the recognition of replication origins and the assembly of the pre-replicative complex, ensuring accurate DNA replication. Abnormal expression or mutations in ORC2L are linked to various proliferative diseases, including different types of cancer. Studies have shown that ORC2L not only functions in the nuclear environment but also interacts with various cellular pathways that influence cell proliferation and survival. Moreover, the significance of ORC2L extends beyond replication as it may also have roles in transcription regulation and chromatin remodeling. Understanding the structural and functional dynamics of ORC2L through recombinant protein studies can provide insights into its mechanisms of action, potential regulatory functions, and its interactions with other cellular components. This knowledge could pave the way for novel therapeutic strategies targeting its associated pathways in tumorigenesis and other replication-related disorders. As research continues to unravel the complexities of ORC2L, it remains a promising focus for understanding fundamental processes in cell biology and disease mechanisms.
