Analytical Data
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基因名
AP5Z1
- Application
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别名
AP5Z1; KIAA0415; SPG48AP-5 complex subunit zeta-1; Adaptor-related Protein complex 5 zeta subunit; Zeta5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43299
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表达区间
1-446aa
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氨基酸序列
MAKVVVLSPGTLQEDQATLLSKRLVDWLRYASLQQGLPHSGGFFSTPRARQPGPVTEVDGAVATDFFTVLSSGHRFTDDQWLNVQAFSMLRAWLLHSGPEGPGTLDTDDRSEQEGSTLSVISATSSAGRLLPPRERLREVAFEYCQRLIEQSNRRALRKGDSDLQKACLVEAVLVLDVLCRQDPSFLYRSLSCLKALHGRVRGDPASVRVLLPLAHFFLSHGEAAAVDSEAVYQHLFTRIPVEQFHSPMLAFEFIQFCRDNLHLFSGHLSTLRLSFPNLFKFLAWNSPPLTSEFVALLPALVDAGTALEMLHALLDLPCLTAVLDLQLRSAPAASERPLWDTSLRAPSCLEAFRDPQFQGLFQYLLRPKASGATERLAPLHQLLQPMAGCARVAQCAQAVPTLLQAFFSAVTQVADGSLINQLALLLLGRSDSLYPAPGYAAGVHR
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分子量
74.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP5Z1, a member of the AP-5 complex, is an important protein involved in intracellular trafficking and membrane protein sorting. Research into AP5Z1 has gained traction due to its potential role in neurodevelopment and synaptic function. Disruptions in the function of AP5Z1 have been implicated in various neurodegenerative disorders, making it a target of interest for understanding disease mechanisms and developing therapeutic strategies. The protein is primarily expressed in the nervous system, suggesting that it may have unique roles in neuronal communication and plasticity. Recent studies have highlighted its potential interactions with other proteins involved in endosomal transport and signaling pathways. As the complexities of protein networks in cellular environments are unveiled, investigating the precise mechanisms by which AP5Z1 contributes to these processes could provide insights into therapeutic interventions for neurodevelopmental disorders and related conditions. Therefore, further elucidation of the functional properties and regulatory mechanisms of AP5Z1 is essential for advancing our knowledge of its biology and its implications in health and disease.
