Analytical Data
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Gene name
AP5Z1
- Application
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Alternative Names
AP5Z1; KIAA0415; SPG48AP-5 complex subunit zeta-1; Adaptor-related Protein complex 5 zeta subunit; Zeta5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43299
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Expression Region
1-446aa
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AA Sequence
MAKVVVLSPGTLQEDQATLLSKRLVDWLRYASLQQGLPHSGGFFSTPRARQPGPVTEVDGAVATDFFTVLSSGHRFTDDQWLNVQAFSMLRAWLLHSGPEGPGTLDTDDRSEQEGSTLSVISATSSAGRLLPPRERLREVAFEYCQRLIEQSNRRALRKGDSDLQKACLVEAVLVLDVLCRQDPSFLYRSLSCLKALHGRVRGDPASVRVLLPLAHFFLSHGEAAAVDSEAVYQHLFTRIPVEQFHSPMLAFEFIQFCRDNLHLFSGHLSTLRLSFPNLFKFLAWNSPPLTSEFVALLPALVDAGTALEMLHALLDLPCLTAVLDLQLRSAPAASERPLWDTSLRAPSCLEAFRDPQFQGLFQYLLRPKASGATERLAPLHQLLQPMAGCARVAQCAQAVPTLLQAFFSAVTQVADGSLINQLALLLLGRSDSLYPAPGYAAGVHR
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Molecular Weight
74.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
AP5Z1, a member of the AP-5 complex, is an important protein involved in intracellular trafficking and membrane protein sorting. Research into AP5Z1 has gained traction due to its potential role in neurodevelopment and synaptic function. Disruptions in the function of AP5Z1 have been implicated in various neurodegenerative disorders, making it a target of interest for understanding disease mechanisms and developing therapeutic strategies. The protein is primarily expressed in the nervous system, suggesting that it may have unique roles in neuronal communication and plasticity. Recent studies have highlighted its potential interactions with other proteins involved in endosomal transport and signaling pathways. As the complexities of protein networks in cellular environments are unveiled, investigating the precise mechanisms by which AP5Z1 contributes to these processes could provide insights into therapeutic interventions for neurodevelopmental disorders and related conditions. Therefore, further elucidation of the functional properties and regulatory mechanisms of AP5Z1 is essential for advancing our knowledge of its biology and its implications in health and disease.
