Analytical Data
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基因名
AP3M2
- Application
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别名
AP3M2; AP-3 complex subunit mu-2; Adaptor-related Protein complex 3 subunit mu-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P53677
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表达区间
1-418aa
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氨基酸序列
MIHSLFLINS SGDIFLEKHW KSVVSRSVCD YFFEAQERAT EAENVPPVIP TPHHYLLSVY RHKIFFVAVI QTEVPPLFVI EFLHRVVDTF QDYFGVCSEP VIKDNVVVVY EVLEEMLDNG FPLATESNIL KELIKPPTIL RTVVNTITGS TNVGDQLPTG QLSVVPWRRT GVKYTNNEAY FDVIEEIDAI IDKSGSTITA EIQGVIDACV KLTGMPDLTL SFMNPRLLDD VSFHPCVRFK RWESERILSF IPPDGNFRLL SYHVSAQNLV AIPVYVKHNI SFRDSSSLGR FEITVGPKQT MGKTIEGVTV TSQMPKGVLN MSLTPSQGTH TFDPVTKMLS WDVGKINPQK LPSLKGTMSL QAGASKPDEN PTINLQFKIQ QLAISGLKVN RLDMYGEKYK PFKGIKYMTK AGKFQVRT
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分子量
46.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP3M2 (AP-3 complex subunit mu 2) is a key protein involved in the formation and function of clathrin-associated protein complexes, specifically the adaptor protein complex 3 (AP-3). This complex plays a crucial role in the intracellular trafficking and sorting of proteins to lysosomes and other organelles. AP3M2 has gained attention due to its implications in various cellular processes, including the regulation of synaptic vesicle trafficking and the maintenance of cellular homeostasis. Mutations in the AP3M2 gene have been associated with several genetic disorders, including neurological conditions and other developmental issues, highlighting its significance in human health. Research on the recombinant AP3M2 protein seeks to elucidate its structural properties and functional mechanisms, providing insights into its role in cellular pathways and potential therapeutic targets. Studies utilizing recombinant AP3M2 can help in understanding its interactions with other proteins within the AP-3 complex, facilitating a deeper knowledge of how these interactions influence protein sorting and secretion. By characterizing this protein, researchers aim to create a platform for drug discovery and development, targeting diseases linked to dysregulation of AP-3 function. Overall, the investigation into AP3M2’s properties and functions represents a promising area of research with the potential to advance our understanding of intracellular transport systems and their implications in health and disease.
