Analytical Data
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Gene name
TIAL1
- Application
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Alternative Names
TIAL1；Nucleolysin TIAR
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P31483
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Expression Region
1-386aa
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AA Sequence
MEDEMPKTLY VGNLSRDVTE ALILQLFSQI GPCKNCKMIM DTAGNDPYCF VEFHEHRHAA AALAAMNGRK IMGKEVKVNW ATTPSSQKKD TSSSTVVSTQ RSQDHFHVFV GDLSPEITTE DIKAAFAPFG RISDARVVKD MATGKSKGYG FVSFFNKWDA ENAIQQMGGQ WLGGRQIRTN WATRKPPAPK STYESNTKQL SYDEVVNQSS PSNCTVYCGG VTSGLTEQLM RQTFSPFGQI MEIRVFPDKG YSFVRFNSHE SAAHAIVSVN GTTIEGHVVK CYWGKETLDM INPVQQQNQI GYPQPYGQWG QWYGNAQQIG QYMPNGWQVP AYGMYGQAWN QQGFNQTQSS APWMGPNYGV QPPQGQNGSM LPNQPSGYRV AGYETQ
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TIAL1, or T-cell intracellular antigen 1, is an RNA-binding protein that plays a critical role in post-transcriptional regulation of gene expression and is involved in various biological processes, including cell differentiation, proliferation, and apoptosis. Its importance is underscored by its involvement in immune responses and potential implications in cancer biology, where dysregulation of TIAL1 has been linked to tumor progression. Recent studies have revealed that TIAL1 interacts with multiple RNA targets, influencing their stability and translation, making it a significant factor in the control of gene expression. The investigation of TIAL1 as a recombinant protein provides valuable insights into its structural and functional properties, as well as its interaction mechanisms with other cellular factors. By producing TIAL1 as a recombinant protein, researchers aim to elucidate its role in various cellular pathways, explore potential therapeutic applications, and develop new strategies for targeting TIAL1 in disease contexts. Understanding the molecular intricacies of TIAL1 can thus contribute to advancing our knowledge of cellular regulation and highlight its potential as a biomarker or therapeutic target in diseases where its expression is aberrant.
