Analytical Data
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基因名
TFB2M
- Application
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别名
TFB2M;NS5ATP5;Dimethyladenosine transferase 2. mitochondrial
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H5Q4
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表达区间
20-396aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMAGRFCILGSEAATRKHLPARNHCGLS DSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLAQIYLGKPSRP PHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLR VIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMF PSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPD LYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQK LYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPL DARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLED R
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分子量
46 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TFB2M, or Transcription Factor B2 Mitochondrial, is a key protein involved in the transcription regulation of mitochondrial DNA. As a vital component of the mitochondrial transcription machinery, TFB2M plays a significant role in the maintenance of mitochondrial function, which is essential for cellular metabolism and energy production. The study of TFB2M is crucial due to its direct implications in mitochondrial biogenesis and the regulation of gene expression within mitochondria. Dysfunction in mitochondrial proteins, including TFB2M, has been linked to a range of diseases, such as mitochondrial myopathies, neurodegenerative disorders, and certain types of cancer. Research has shown that TFB2M interacts with other mitochondrial transcription factors and is important for the initiation of transcription by RNA polymerase, ultimately influencing the synthesis of mitochondrial proteins that are critical for oxidative phosphorylation. Given the increasing recognition of the importance of mitochondrial health in overall cellular function and the development of various diseases, understanding the molecular mechanisms of TFB2M and its regulatory pathways has become a pivotal area of investigation. Recent advances in biotechnology and structural biology have enabled researchers to elucidate the functional dynamics of TFB2M, paving the way for potential therapeutic strategies that target mitochondrial dysfunction. By enhancing our knowledge of TFB2M and its role in cellular energy metabolism, the field aims to develop novel interventions for diseases rooted in mitochondrial impairment.












