Analytical Data
-
Gene name
TFB1M
- Application
-
Alternative Names
TFB1M；Dimethyladenosine transferase 1. mitochondrial
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8WVM0
-
Expression Region
28-346aa
-
AA Sequence
MGSSHHHHHHSSGLVPRGSHMQAAKQLSQNFLLDLRLTDKIVRKAGNLTN AYVYEVGPGPGGITRSIL NADVAELLVVEKDTRFIPGLQMLSDAAPGK LRIVHGDVLTFKVEKAFSESLKRPWEDDPPNVHIIGNLPFSVSTP LII KWLENISCRDGPFVYGRTQMTLTFQKEVAERLAANTGSKQRSRLSVMAQY LCNVRHIFTIPGQAFVPKPEVD VGVVHFTPLIQPKIEQPFKLVEKVVQ NVFQFRRKYCHRGLRMLFPEAQRLESTGRLLELADIDPTLRPRQLSISH FKSLCDVYRKMCDEDPQLFAYNFREELKRRKSKNEEKEEDDAENYRL
-
Molecular Weight
39 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TFB1M, or Transcription Factor B1M, is a crucial mitochondrial transcription factor that plays a significant role in the regulation of mitochondrial gene expression. It is involved in the assembly of the mitochondrial transcription initiation complex, which is essential for the transcription of mitochondrial DNA (mtDNA). The study of TFB1M has garnered attention due to its potential implications in various diseases, particularly those associated with mitochondrial dysfunction, such as neurodegenerative disorders, cancer, and metabolic syndromes. Researchers have been focusing on the structural and functional characterization of TFB1M to better understand its mechanism of action in mitochondrial transcription regulation. Gaining insights into TFB1M's role could lead to the development of therapeutic strategies aimed at correcting mitochondrial dysfunctions. Additionally, investigations into its interactions with other mitochondrial proteins may provide valuable information about the intricate networks that govern mitochondrial biology. Given the increasing recognition of mitochondria's impact on cellular health and disease, TFB1M stands out as a significant target for research aimed at unraveling the complexities of mitochondrial gene regulation and its broader implications in human health. This research is not only pivotal for basic science but also holds promise for translational applications in therapies for mitochondrial-related diseases.
