Analytical Data
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基因名
ANKK1
- Application
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别名
ANKK1; PKK2; SGK288Ankyrin repeat and Protein kinase domain-containing Protein 1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NFD2
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表达区间
1-765aa
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氨基酸序列
MAADPTELRLGSLPVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAAKMKKIKFQHIVSIYGVCKQPLGIVMEFMANGSLEKVLSTHSLCWKLRFRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSALRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAGMRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSVATLGGSKPGAEMEI
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分子量
84.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ANKK1 (ankyrin repeat and kinase domain containing 1) is a gene that encodes a protein involved in various cellular processes, including signal transduction and neuronal function. Research has found ANKK1 to be associated with various psychological and neurodegenerative disorders, including Parkinson's disease and addiction. The relevance of ANKK1 in dopamine signaling pathways, particularly those involving D2 dopamine receptors, has garnered interest due to its potential implications for understanding the neurobiological underpinnings of these conditions. Given its pivotal role, the expression and functional characterization of recombinant ANKK1 protein have become a focal point in neurobiological research. By producing ANKK1 as a recombinant protein, scientists aim to elucidate its structural properties, enzymatic activity, and interactions with other proteins. This approach not only aids in understanding the molecular mechanisms of disease but also has therapeutic potential. The study of ANKK1 reconstituted in vitro allows for controlled experimental conditions, shedding light on its role in cell signaling pathways. Furthermore, understanding the structure-function relationship of this protein could lead to the development of targeted therapies, particularly for disorders influenced by dopamine dysregulation. Thus, ongoing research on ANKK1 recombinant protein represents a crucial avenue for unlocking new insights into complex neurological and psychiatric disorders.
