Analytical Data
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Gene name
TBCC
- Application
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Alternative Names
TBCC;Tubulin-specific chaperone C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15814
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Expression Region
2-345aa
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AA Sequence
ESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFVRERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQW
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Molecular Weight
43.0kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBCC (Tubulin folding Cofactor C) is a crucial protein involved in the proper folding and assembly of tubulin, a key component of microtubules that are essential for various cellular processes, including cell division, intracellular transport, and maintaining cell shape. Research on TBCC has gained significant attention due to its potential implications in neurodegenerative diseases and cancer, where microtubule dynamics are often disrupted. Malfunctions in TBCC can lead to improper tubulin assembly, resulting in altered cellular functions and possibly contributing to disease pathogenesis. Scientists are exploring TBCC's structure and dynamics at the molecular level to understand its role in microtubule biogenesis and to identify potential therapeutic targets for diseases characterized by cytoskeletal dysfunction. Advances in recombinant protein technology have enabled the production of highly pure TBCC, facilitating detailed biochemical and biophysical studies. This research aims not only to unravel the mechanisms of microtubule assembly but also to provide insights into novel therapeutic strategies that could harness the modulation of TBCC activity to treat diseases associated with cytoskeletal abnormalities.











