Analytical Data
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基因名
TBC1D13
- Application
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别名
TBC1D13；TBC1 domain family member 13
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NVG8
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表达区间
1-400aa
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氨基酸序列
MSSLHKSRIA DFQDVLKEPS IALEKLRELS FSGIPCEGGL RCLCWKILLN YLPLERASWT SILAKQRELY AQFLREMIIQ PGIAKANMGV SREDVTFEDH PLNPNPDSRW NTYFKDNEVL LQIDKDVRRL CPDISFFQRA TDYPCLLILD PQNEFETLRK RVEQTTLKSQ TVARNRSGVT NMSSPHKNSV PSSLNEYEVL PNGCEAHWEV VERILFIYAK LNPGIAYVQG MNEIVGPLYY TFATDPNSEW KEHAEADTFF CFTNLMAEIR DNFIKSLDDS QCGITYKMEK VYSTLKDKDV ELYLKLQEQN IKPQFFAFRW LTLLLSQEFL LPDVIRIWDS LFADDNRFDF LLLVCCAMLM LIREQLLEGD FTVNMRLLQD YPITDVCQIL QKAKELQDSK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBC1D13 is a member of the TBC (Tre-2/Bub2/CDC16) domain-containing protein family, which plays a crucial role in cellular processes such as endocytosis, autophagy, and the regulation of vesicular trafficking. Research has identified TBC1D13 as a GTPase-activating protein (GAP) for Rab GTPases—molecules essential for intracellular trafficking. Its involvement in the regulation of Rab proteins indicates a significant role in maintaining cellular homeostasis. Recent studies have linked TBC1D13 to various cellular functions, including the modulation of autophagic pathways and its potential implications in diseases such as cancer, neurodegeneration, and metabolic disorders. Moreover, mutations and dysregulation of TBC1D13 have been associated with pathological states, highlighting its relevance in health and disease. Understanding the function and mechanism of TBC1D13 is critical, as it could lead to insights into the molecular underpinnings of these conditions and possibly provide novel therapeutic targets. The exploration of TBC1D13 recombinant proteins could further elucidate its biological functions, interactions, and regulatory mechanisms in various cellular contexts, thereby advancing our understanding of its role in health and disease.
