Analytical Data
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Gene name
TATDN1
- Application
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Alternative Names
TATDN1；Deoxyribonuclease TATDN1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6P1N9
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Expression Region
1-297aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMSRFKFI DIGINLTDPM FRGIYRGVQK HQDDLQDVIG RAVEIGVKKF MITGGNLQDS KDALHLAQTN GMFFSTVGCH PTRCGEFEKN NPDLYLKELL NLAENNKGKV VAIGECGLDF DRLQFCPKDT QLKYFEKQFE LSEQTKLPMF LHCRNSHAEF LDIMKRNRDR CVGGVVHSFD GTKEAAAALI DLDLYIGFNG CSLKTEANLE VLKSIPSEKL MIETDAPWCG VKSTHAGSKY IRTAFPTKKK WESGHCLKDR NEPCHIIQIL EIMSAVRDED PLELANTLYN NTIKVFFPGI
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Molecular Weight
36 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TATDN1, or TATA-Box Binding Protein Associated Factor, has gained attention in recent years due to its role in regulating gene expression and its potential implications in various biological processes. This protein is part of the transcriptional machinery and is involved in the assembly of the transcriptional pre-initiation complex, crucial for RNA polymerase II-mediated transcription. Dysregulation of TATDN1 has been associated with several diseases, including cancer, where it may influence tumorigenesis through aberrant gene expression patterns. The study of TATDN1 recombinant proteins has become a focal point for understanding its structural and functional characteristics, which can elucidate its role in transcriptional regulation. Researchers aim to produce TATDN1 in a recombinant form to investigate its interactions with other transcription factors and DNA, providing insights into the molecular mechanisms that govern gene expression. By utilizing techniques such as protein purification and characterization, scientists hope to establish a clearer understanding of TATDN1's functions and its potential as a therapeutic target. Overall, the research into TATDN1 recombinant proteins is critical for revealing the complexities of transcriptional regulation and could pave the way for novel therapeutic interventions in diseases linked to transcriptional dysregulation.
