Analytical Data
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Gene name
CHD8
- Application
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Alternative Names
CHD8；HELSNF1；KIAA1564；Chromodomain-helicase-DNA-binding Protein 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HCK8
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
290 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHD8 (Chromodomain Helicase DNA-binding protein 8) is a crucial chromatin remodeling factor that has garnered significant interest in the fields of neurodevelopmental disorders and cancer research. Mutations in the CHD8 gene have been linked to autism spectrum disorders (ASD), underlining its importance in brain development and function. CHD8 is known to play a fundamental role in gene regulation by influencing chromatin structure and accessibility, thus affecting the transcription of target genes involved in neuronal differentiation and synaptic function. The study of CHD8 recombinant proteins provides insights into its biochemical and biophysical properties, enabling researchers to elucidate the molecular mechanisms underlying its function. By investigating the interactions of CHD8 with various chromatin-associated proteins and its role in the epigenetic landscape, scientists aim to uncover the pathways that contribute to neurodevelopmental disorders and the potential therapeutic targets for ASD and related conditions. Additionally, as CHD8 is implicated in malignancies, understanding its function at a molecular level could provide valuable information for developing novel strategies in cancer therapy. Overall, CHD8 serves as a vital player in the intersection of developmental biology and disease, making its study pivotal for advancements in both basic research and clinical applications.
