Analytical Data
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Gene name
STAP1
- Application
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Alternative Names
STAP1；BRDG1；Signal-transducing adaptor Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9ULZ2
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Expression Region
1-295aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMMAKKP PKPAPRRIFQ ERLKITALPL YFEGFLLIKR SGYREYEHYW TELRGTTLFF YTDKKSIIYV DKLDIVDLTC LTEQNSTEKN CAKFTLVLPK EEVQLKTENT ESGEEWRGFI LTVTELSVPQ NVSLLPGQVI KLHEVLEREK KRRIETEQST SVEKEKEPTE DYVDVLNPMP ACFYTVSRKE ATEMLQKNPS LGNMILRPGS DSRNYSITIR QEIDIPRIKH YKVMSVGQNY TIELEKPVTL PNLFSVIDYF VKETRGNLRP FICSTDENTG QEPSMEGRSE KLKKNPHIA
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STAP1 (Signaling Threshold Adjuster 1) is a crucial protein involved in various cellular signaling pathways, particularly those related to immune responses and hematopoiesis. Its role in T-cell signaling and activation has garnered significant research interest, especially in the context of autoimmune diseases and cancers. Recent studies have highlighted that STAP1 functions as an adaptor protein, modulating the activity of several key signaling molecules, such as protein tyrosine kinases and phosphatases. Dysregulation of STAP1 expression has been linked to abnormal cell proliferation and immune dysfunction, indicating its potential as a therapeutic target. Researchers have focused on the characterization and purification of recombinant STAP1 protein to understand its structure-function relationship better and explore its mechanisms in cellular signaling. Additionally, the development of STAP1 as a biomarker or therapeutic target in various diseases promises to enhance our understanding of immune regulation and pave the way for novel treatment strategies, emphasizing the need for continued investigation into its biological roles and implications in health and disease.
