Analytical Data
-
基因名
CDC14
- Application
-
别名
CDC14；Dual specificity Protein phosphatase CDC14A
-
种属
E.coli
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q59NH8
-
表达区间
1-542aa
-
氨基酸序列
MHSSSVHVPLIEFLKNRIYLGAYDHHKRDTEDLAYFTVEDALPYNAFYMDFGPLNIGHLYRFAVLLHKKLNEDSTQGKGLVIYSSTSPKERANLACLLCCYMILLQNWAPHQVLQPIAQITPPLQAFRDAGYSSADYEITIQDVVYAMWRAKERGMIDLAKFDLDEYEQYERVDQGDFNVISKDFIAFASPQQSKRGGLNEPFQKVLEYFVENNVQLVVRLNSHLYDAKEFTKRNIKHIDMIFDDGTCPTLEYVQKFIGAAECIINKGGKIAVHCKAGLGRTGCLIGAHLIYTHGFTANECIAYMRMIRPGMVVGPQQHWLYLHHDDFRSWRHTMIVDNRPDPLIGNLFPLCSYEDYKQRLKEAKRKERLQLQQQLTSPLADSSVINTPIRRRKVSGALASKIQTVVPIESPGQPRKYFEDSEDIDEVEMVNNSDDENTMQDIIQSSPARYDSVTPKTKDNSDWRVLRSISTNNVSSQQSIHIIKTTTTKTVNETLSSPPGTSPTNVLRVSKARSKNRIASGNSQTSRAHSGGVRKLSGKKH
-
分子量
61.5 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CDC14 is a crucial protein phosphatase that plays a significant role in cell cycle regulation, particularly during mitosis and cytokinesis. It is known for its function in the dephosphorylation of key substrates, thereby ensuring the proper timing and progression of the cell cycle. Dysregulation of CDC14 activity is associated with various diseases, including cancer, highlighting its potential as a therapeutic target. Research has focused on understanding the mechanisms underlying CDC14 regulation, its interaction with other cell cycle proteins, and its role in the DNA damage response. Recombination studies involving CDC14 have aimed to elucidate its structure-function relationships, paving the way for the development of specific inhibitors or modulators that could influence cell cycle dynamics in cancer cells. This understanding not only provides insights into fundamental cellular processes but also opens avenues for novel cancer therapies that exploit the vulnerabilities of tumor cells exploiting the cell cycle machinery. As such, the research on CDC14 recombinant proteins is of significant interest in the fields of cell biology and pharmacology.
