Analytical Data
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基因名
ADSS
- Application
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别名
ADSS2; ADSS; Adenylosuccinate synthetase isozyme 2; AMPSase 2; AdSS 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30520
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表达区间
1-456aa
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氨基酸序列
MAFAETYPAA SSLPNGDCGR PRARPGGNRV TVVLGAQWGD EGKGKVVDLL AQDADIVCRC QGGNNAGHTV VVDSVEYDFH LLPSGIINPN VTAFIGNGVV IHLPGLFEEA EKNVQKGKGL EGWEKRLIIS DRAHIVFDFH QAADGIQEQQ RQEQAGKNLG TTKKGIGPVY SSKAARSGLR MCDLVSDFDG FSERFKVLAN QYKSIYPTLE IDIEGELQKL KGYMEKIKPM VRDGVYFLYE ALHGPPKKIL VEGANAALLD IDFGTYPFVT SSNCTVGGVC TGLGMPPQNV GEVYGVVKAY TTRVGIGAFP TEQDNEIGEL LQTRGREFGV TTGRKRRCGW LDLVLLKYAH MINGFTALAL TKLDILDMFT EIKVGVAYKL DGEIIPHIPA NQEVLNKVEV QYKTLPGWNT DISNARAFKE LPVNAQNYVR FIEDELQIPV KWIGVGKSRE SMIQLF
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分子量
50 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADSS (adenylosuccinate synthetase) is a crucial enzyme in the purine nucleotide synthesis pathway, playing an essential role in the biosynthesis of adenine nucleotides. Research into ADSS has gained prominence due to its implications in human health and disease, particularly in the context of metabolic disorders. Mutations in the gene encoding for ADSS can lead to a rare genetic disorder known as adenylosuccinate lyase deficiency, which is characterized by neurological problems and developmental delays. Understanding the structure and function of ADSS is vital for elucidating its role in cellular metabolism and its potential as a therapeutic target. Recent advances in recombinant protein technology have enabled the production of ADSS in various expression systems, facilitating detailed biochemical and structural studies. These efforts aim to uncover the enzymatic mechanisms of ADSS and its regulatory pathways, which could lead to innovative strategies for treating associated disorders. As researchers continue to explore the functionality and dynamics of ADSS, there is growing interest in its potential role in cancer metabolism and other diseases, making it a significant focus in the field of molecular biology and medicine.
