Analytical Data
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基因名
ETV5
- Application
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别名
ETV5；ERM；ETS translocation variant 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41161
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表达区间
1-510aa
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氨基酸序列
MASMTGGQQMGRGHHHHHHENLYFQGGEFDGFYDQQVPFMVPGKSRSEEC RGRPVIDRKRKFLDTDLAHDSEELFQDLSQLQEAWLAEAQVPDDEQFVPD FQSDNLVLHAPPPTKIKRELHSPSSELSSCSHEQALGANYGEKCLYNYCA YDRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTSGHAPAAGPVQGV GPAPAPHSLPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRFQRQL SEPCHPFPPQPGVPGDNRPSYHRQMSEPIVPAAPPPPQGFKQEYHDPLYE HGVPGMPGPPAHGFQSPMGIKQEPRDYCVDSEVPNCQSSYMRGGYFSSSH EGFSYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGPPYQRRGSLQLWQ FLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKL SRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPFLKAESE CHLSEEDTLPLTHFEDSPAYLLDMDRCSSLPYAEGFAY
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分子量
61 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ETV5, a member of the Ets family of transcription factors, plays a pivotal role in various cellular processes, including differentiation, proliferation, and apoptosis. Its expression is closely linked to several physiological and pathological conditions, particularly in cancer biology. Research has shown that ETV5 is often overexpressed in various malignancies, such as prostate cancer, where it can promote tumor progression by regulating genes involved in cellular growth and survival. Additionally, ETV5 is implicated in the epithelial-to-mesenchymal transition (EMT), a crucial mechanism in cancer metastasis. Given its significant role in tumorigenesis, understanding the structure and function of ETV5 is essential for developing targeted therapies. Recent studies have focused on the recombinant expression of ETV5 to investigate its functional domains and interaction with other molecular players in tumorigenesis. This research aims to elucidate the exact mechanisms by which ETV5 influences cancer progression and to explore its potential as a therapeutic target. By generating ETV5 recombinant proteins, researchers can perform in-depth analyses, including binding affinity studies and functional assays, to enhance our understanding of its regulatory roles in gene expression and tumor behavior. This ongoing research underscores the importance of ETV5 in cancer biology and its potential in designing innovative strategies for cancer treatment.
