Analytical Data
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Gene name
ADRBK1
- Application
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Alternative Names
ADRBK1; Adrenergic beta receptor kinase 1; ARBK1_HUMAN; BARK
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25098
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Expression Region
2-221aa
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AA Sequence
ADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKC
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Molecular Weight
79.5 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADRBK1, also known as beta-arrestin kinase 1, is a serine/threonine kinase that plays a critical role in the regulation of G protein-coupled receptors (GPCRs) signaling pathways. These pathways are crucial for various physiological processes, including cell communication, metabolism, and immune responses. Dysregulation of ADRBK1 has been linked to several diseases, including cardiovascular issues, obesity, and cancer, making it an important target for therapeutic intervention. Recent studies have focused on the recombinant production of ADRBK1 protein, allowing researchers to explore its structure, function, and interactions in detail. This recombinant protein can be utilized in biochemical assays to investigate its kinase activity, influence on receptor desensitization and internalization, and potential interactions with other signaling proteins. Understanding the role of ADRBK1 in GPCR signaling not only enhances our knowledge of cellular processes but also provides insights into novel drug development strategies aimed at modulating this important signaling pathway for therapeutic benefits.
