Analytical Data
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基因名
ADRBK1
- Application
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别名
ADRBK1; Adrenergic beta receptor kinase 1; ARBK1_HUMAN; BARK
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P25098
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表达区间
2-221aa
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氨基酸序列
ADLEAVLADVSYLMAMEKSKATPAARASKKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKC
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分子量
79.5 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADRBK1, also known as beta-arrestin kinase 1, is a serine/threonine kinase that plays a critical role in the regulation of G protein-coupled receptors (GPCRs) signaling pathways. These pathways are crucial for various physiological processes, including cell communication, metabolism, and immune responses. Dysregulation of ADRBK1 has been linked to several diseases, including cardiovascular issues, obesity, and cancer, making it an important target for therapeutic intervention. Recent studies have focused on the recombinant production of ADRBK1 protein, allowing researchers to explore its structure, function, and interactions in detail. This recombinant protein can be utilized in biochemical assays to investigate its kinase activity, influence on receptor desensitization and internalization, and potential interactions with other signaling proteins. Understanding the role of ADRBK1 in GPCR signaling not only enhances our knowledge of cellular processes but also provides insights into novel drug development strategies aimed at modulating this important signaling pathway for therapeutic benefits.
