Analytical Data
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Gene name
SNX5
- Application
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Alternative Names
SNX5;Sorting nexin-5
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5X3
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Expression Region
1-404aa
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AA Sequence
MASMTGGQQMGRGEFMAAVPELLQQQEEDRSKLRSVSVDLNVDPSLQIDI PDALSERDKVKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDY AGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMKQELEAEYLAV FKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFGG FFKSVVKSADEVLFTGVKEVDDFFEQEKNFLINYYNRIKDSCVKADKMTR SHKNVADDYIHTAACLHSLALEEPTVIKKYLLKVAELFEKLRKVEGRVSS DEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKD VKLAEAHQQECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSELEIK HARNNVSLLQSCIDLFKNN
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Molecular Weight
48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNX5 (Sorting Nexin 5) is a member of the sorting nexin family, which plays a crucial role in intracellular trafficking and membrane dynamics. Research has shown that SNX5 is involved in various cellular processes, including endocytosis, autophagy, and the sorting of membrane proteins. Its function is particularly significant in the context of immune responses and cellular signaling pathways. Abnormalities in SNX5 expression or function have been implicated in several diseases, including cancer and neurodegenerative disorders. Given its pivotal role in cellular processes, studying recombinant SNX5 proteins has become essential for understanding the mechanisms underlying its function and regulation. Researchers aim to express and purify SNX5 proteins to investigate their structural properties and interactions with other cellular components. This research is critical for elucidating its biological roles and discovering potential therapeutic targets, as manipulating SNX5 activity could pave the way for novel treatments in conditions where its functionality is disrupted. Through advanced techniques such as crystallography and biophysical assays, insights gained from these studies will contribute significantly to the broader knowledge of membrane trafficking and its implications in health and disease.
