Analytical Data
-
Gene name
OAZ3
- Application
-
Alternative Names
OAZ3；Ornithine decarboxylase antizyme 3
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9UMX2
-
Expression Region
1-187aa
-
AA Sequence
MLPRCYKSIT YKEEEDLTLQ PRSCLQCSES LVGLQEGKST EQGNHDQLKE LYSAGNLTVL ATDPLLHQDP VQLDFHFRLT SQTSAHWHGL LCDRRLFLDI PYQALDQGNR ESLTATLEYV EEKTNVDSVF VNFQNDRNDR GALLRAFSYM GFEVVRPDHP ALPPLDNVIF MVYPLERDVG HLPSEPP
-
Molecular Weight
27.4 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
OAZ3 (ornithine decarboxylase antizyme 3) is a relatively novel protein that belongs to the antizyme family, which plays a crucial role in the regulation of polyamine synthesis and cellular proliferation. The background research on OAZ3 has gained momentum due to its potential implications in various biological processes, including cancer development and cellular stress responses. Polyamines, such as putrescine, spermidine, and spermine, are essential for cell growth and differentiation; however, their dysregulation is often linked to several pathological conditions, including tumorigenesis. OAZ3 modulates the activity of ornithine decarboxylase (ODC), the rate-limiting enzyme in polyamine biosynthesis, thereby serving as a key regulatory molecule. Recent studies suggest that OAZ3 may also have distinct functions beyond antizyme activity, such as involvement in cellular signaling pathways and interactions with various biomolecules. Given the complex roles that polyamines and OAZ3 play in cellular homeostasis, there is a growing interest in understanding the biochemical and molecular mechanisms governing OAZ3 function. Researchers aim to elucidate its role in cancer biology, potential as a biomarker, and therapeutic target. Additionally, the structural characterization of OAZ3 may provide insights into its functional mechanisms and interactions within the cell. Overall, the ongoing research on OAZ3 is essential for uncovering new therapeutic avenues and understanding the broader implications of polyamine regulation in health and disease.
