Analytical Data
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基因名
ADAMTS15
- Application
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别名
ADAM TS 15; ADAM TS15; ADAM-TS 15; ADAM-TS15; ADAMTS 15; ADAMTS-15; ADAMTS15
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TE58
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表达区间
213-950aa
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氨基酸序列
FVSIPRYV ETLVVADESM VKFHGADLEH YLLTLLATAA RLYRHPSILN PINIVVVKVL LLRDRDSGPK VTGNAALTLR NFCAWQKKLN KVSDKHPEYW DTAILFTRQD LCGATTCDTL GMADVGTMCD PKRSCSVIED DGLPSAFTTA HELGHVFNMP HDNVKVCEEV FGKLRANHMM SPTLIQIDRA NPWSACSAAI ITDFLDSGHG DCLLDQPSKP ISLPEDLPGA SYTLSQQCEL AFGVGSKPCP YMQYCTKLWC TGKAKGQMVC QTRHFPWADG TSCGEGKLCL KGACVERHNL NKHRVDGSWA KWDPYGPCSR TCGGGVQLAR RQCTNPTPAN GGKYCEGVRV KYRSCNLEPC PSSASGKSFR EEQCEAFNGY NHSTNRLTLA VAWVPKYSGV SPRDKCKLIC RANGTGYFYV LAPKVVDGTL CSPDSTSVCV QGKCIKAGCD GNLGSKKRFD KCGVCGGDNK SCKKVTGLFT KPMHGYNFVV AIPAGASSID IRQRGYKGLI GDDNYLALKN SQGKYLLNGH FVVSAVERDL VVKGSLLRYS GTGTAVESLQ ASRPILEPLT VEVLSVGKMT PPRVRYSFYL PKEPREDKSS HPKDPRGPSV LHNSVLSLSN QVEQPDDRPP ARWVAGSWGP CSASCGSGLQ KRAVDCRGSA GQRTVPACDA AHRPVETQAC GEPCPTWELS AWSPCSKSCG RGFQRRSLKC VGHGGRLLAR DQCNLHRKPQ ELDFCVLRPC
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分子量
103.2 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ADAMTS15 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 15) is a member of the ADAMTS family of proteins, which are implicated in various biological processes, including tissue remodeling, angiogenesis, and inflammation. The protein has garnered attention due to its potential roles in developmental biology and various pathological conditions, such as cancer, arthritis, and cardiovascular diseases. Research indicates that ADAMTS15 may contribute to extracellular matrix regulation and could influence tumor microenvironment by modulating the activity of growth factors and cytokines. Recent studies have shown that it is involved in the cleavage of specific matrix components, suggesting a critical role in maintaining tissue homeostasis. As an emerging biomarker, the expression levels of ADAMTS15 have been associated with disease progression and prognosis in several malignancies. Investigating recombinant ADAMTS15 protein facilitates a deeper understanding of its structure-function relationship and mechanisms of action. This research is vital for exploring therapeutic applications, as modulation of ADAMTS15 activity could lead to novel strategies for treating disorders characterized by abnormal matrix remodeling. Overall, the study of ADAMTS15 and its recombinant forms is crucial in understanding its biological significance and potential as a therapeutic target in various diseases.
