Analytical Data
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基因名
ACTR1B
- Application
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别名
Actin related Protein 1B; Actin-related Protein 1B; ACTR 1B; ACTR1B; ACTY_HUMAN; ARP 1B
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42025
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表达区间
1-376aa
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氨基酸序列
MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHMRVMAGALEGDLFIGPKAEEHRGLLTIRYPMEHGVVRDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPSKNREKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVSRYLRLLLRKEGVDFHTSAEFEVVRTIKERACYLSINPQKDEALETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGDESEGLHEVVAFAIHKSDMDLRRTLFANIVLSGGSTLFKGFGDRLLSEVKKLAPKDIKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGSRAIHRKTF
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分子量
68.7 KDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACTR1B, a member of the actin-related protein family, plays a crucial role in cytoskeletal dynamics and intracellular transport. It is an essential component of the dynactin complex, which assists dynein motor proteins in transporting cellular cargos along microtubules. Recent studies have linked ACTR1B to various cellular processes, including mitosis, neuronal function, and the maintenance of cell shape. Mutations or dysregulation of ACTR1B have been implicated in several diseases, particularly neurodegenerative disorders and certain forms of cancer. The recombinant expression of ACTR1B allows researchers to study its structural and functional properties in detail, facilitating a better understanding of its role in cellular mechanisms. Such studies are critical for unraveling the complexities of cellular transport and might pave the way for developing therapeutic strategies targeting ACTR1B-related pathways. Through techniques such as X-ray crystallography and cryo-electron microscopy, scientists aim to elucidate the molecular interactions and conformational changes of ACTR1B within the dynactin complex and its interactions with dynein, enhancing our knowledge of its biological significance. Overall, the investigation of ACTR1B as a recombinant protein is vital for advancing our understanding of cytoskeletal dynamics and its implications in health and disease.
