Analytical Data
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Gene name
ACTR1A
- Application
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Alternative Names
Actin related Protein 1; Actin RPV; Actin-RPV; ACTR 1A; Actr1a; ACTZ_HUMAN; Alpha centractin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P61163
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Expression Region
1-376aa
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AA Sequence
MESYDVIANQ PVVIDNGSGV IKAGFAGDQI PKYCFPNYVG RPKHVRVMAG ALEGDIFIGP KAEEHRGLLS IRYPMEHGIV KDWNDMERIW QYVYSKDQLQ TFSEEHPVLL TEAPLNPRKN RERAAEVFFE TFNVPALFIS MQAVLSLYAT GRTTGVVLDS GDGVTHAVPI YEGFAMPHSI MRIDIAGRDV SRFLRLYLRK EGYDFHSSSE FEIVKAIKER ACYLSINPQK DETLETEKAQ YYLPDGSTIE IGPSRFRAPE LLFRPDLIGE ESEGIHEVLV FAIQKSDMDL RRTLFSNIVL SGGSTLFKGF GDRLLSEVKK LAPKDVKIRI SAPQERLYST WIGGSILASL DTFKKMWVSK KEYEEDGARS IHRKTF
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Molecular Weight
42.6 KDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ACTR1A, or Activator of Chromatin Translation 1A, is a crucial component of the cellular machinery involved in various cellular processes, including intracellular transport and chromatin remodeling. It plays a pivotal role in the dynamics of microtubules and is an essential part of the dynactin complex, which is vital for dynein-mediated transport within cells. Research into ACTR1A has gained traction due to its implications in neurobiology and its potential link to neurodegenerative diseases, where its dysfunction may contribute to impaired cellular transport mechanisms. The study of ACTR1A recombinant proteins helps elucidate its structure-function relationship, enabling scientists to explore how mutations or alterations in its expression can affect cellular functions. Additionally, investigating ACTR1A interactions with other proteins provides insights into the molecular underpinnings of cellular transport, offering potential therapeutic targets for diseases manifesting from transport-related deficits. Moreover, recombinant ACTR1A is employed in various biochemical assays and structural studies, facilitating a deeper understanding of its role within cellular contexts. Overall, the scientific community recognizes the importance of ACTR1A as a vital player in maintaining cellular homeostasis and addressing the broader implications of its dysfunction in human health and disease.
