Analytical Data
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基因名
OPRK1
- Application
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别名
OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41145
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表达区间
1-58 aa
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氨基酸序列
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAI
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分子量
32.12 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The OPRK1 gene encodes the kappa-opioid receptor (KOR), a member of the opioid receptor family that plays a crucial role in modulating pain, mood, and addiction pathways in the central nervous system. KORs have garnered significant interest in pharmacology and neuroscience due to their potential therapeutic applications in managing pain, substance use disorders, and mood disorders. Unlike mu-opioid receptors, which are primarily associated with analgesia and the risk of addiction, KOR activation has been shown to elicit dysphoria and anxiety in some contexts, making it a unique target for drug development. The production of recombinant OPRK1 protein is essential for studying the receptor's structure, function, and potential drug interactions. Advances in recombinant DNA technology have enabled the expression of OPRK1 in various systems, facilitating high-throughput screening of novel ligands that could lead to the development of safer analgesics with reduced addictive properties. Understanding the biological mechanisms underlying KOR signaling and its interaction with different ligands holds promise for discovering new treatment avenues for challenging mental health and pain-related disorders. As research progresses, insightful findings from studies involving recombinant OPRK1 protein may contribute to the design of innovative therapeutics that harness the beneficial aspects of KOR activity while mitigating adverse effects associated with opioid use.
