Analytical Data
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基因名
MC3R
- Application
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别名
MC3R；Melanocortin receptor 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P41968
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表达区间
1-360aa
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氨基酸序列
MSIQKTYLEGDFVFPVSSSSFLRTLLEPQLGSALLTAMNASCCLPSVQPT LPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAV VRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFI QHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALT LIVAIWVCCGVCGVVFIVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLF ARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLV LIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFREI LCGCNGMNLG
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分子量
67 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The melanocortin-3 receptor (MC3R) is a G protein-coupled receptor that plays a crucial role in energy homeostasis, body weight regulation, and influencing food intake. Studies have identified that variations or mutations in the MC3R gene are associated with obesity and metabolic disorders, highlighting its importance in understanding obesity-related pathophysiology. MC3R is predominantly expressed in the central nervous system, particularly in regions of the hypothalamus responsible for appetite regulation. Its ligands, primarily melanocyte-stimulating hormones, activate downstream signaling pathways that modulate appetite and energy expenditure. Research has focused on exploring the receptor's structure, function, and pharmacological properties to better comprehend its role in these critical physiological processes. Recombining the MC3R protein has allowed scientists to study its interactions with various ligands and the consequent signaling mechanisms in controlled settings, paving the way for potential therapeutic interventions in obesity and related metabolic disorders. Understanding MC3R's mechanisms can lead to novel strategies for treating conditions linked to energy imbalance, making it a promising target in the field of metabolic research.
