Analytical Data
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基因名
NUDT8
- Application
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别名
FLJ41567; Nucleoside diphosphate linked moiety X motif 8; Nucleoside diphosphate linked moiety X motif 8 mitochondrial; Nucleoside diphosphate-linked moiety X motif 8. mitochondrial; Nudix (nucleoside diphosphate linked moiety X) type motif 8; Nudix motif 8; Nudix type motif 8; NUDT 8; NUDT8; NUDT8_HUMAN
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WV74
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表达区间
1-140 aa
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氨基酸序列
MLPDCLSAEGELRCRRLLAGATARLRARPASAAVLVPLCSVRGVPALLYTLRSSRLTGRHKGDVSFPGGKCDPADQDVVHTALRETREELGLAVPEEHVWGLLRPVYDPQKATVVPVLAGVGPLDPQSLRPNSEEVSWGI
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分子量
41.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NUDT8, a member of the Nudix hydrolase family, has garnered significant attention in recent years due to its potential roles in cellular metabolism and signaling. This enzyme is known to hydrolyze nucleoside diphosphate sugars, influencing various physiological processes, including nucleotide metabolism and cell signaling pathways. Researchers have focused on NUDT8 due to its implications in cancer biology, as alterations in its activity may affect tumorigenesis and cancer progression. Additionally, NUDT8 is believed to play a crucial role in regulating intracellular levels of nucleotide pools, which are essential for DNA/RNA synthesis and repair, thus impacting overall cell health and function. Recent studies have also suggested that NUDT8 may be involved in the response to oxidative stress, further emphasizing its importance in maintaining cellular homeostasis. The investigation of NUDT8 and its recombinant protein forms aims to elucidate its biochemical properties, functional mechanisms, and potential therapeutic applications, particularly in the context of cancer treatment and metabolic disorders. Understanding the nuances of NUDT8 activity could lead to novel insights into the regulation of nucleotide metabolism and offer new avenues for therapeutic interventions in diseases characterized by disrupted cellular signaling and metabolism. As such, NUDT8 represents a promising target for further research in molecular biology and therapeutic development.
