Cat: PA2000-1221

Recombinant Human GAS8 Protein,His

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Analytical Data

  • Gene name

    GAS8

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    GAS8;DRC4;GAS11;Dynein regulatory complex subunit 4

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    O95995

  • Expression Region

    1-478aa

  • AA Sequence

    MAPKKKGKKG KAKGTPIVDG LAPEDMSKEQ VEEHVSRIRE ELDREREERN YFQLERDKIH TFWEITRRQL EEKKAELRNK DREMEEAEER HQVEIKVYKQ KVKHLLYEHQ NNLTEMKAEG TVVMKLAQKE HRIQESVLRK DMRALKVELK EQELASEVVV KNLRLKHTEE ITRMRNDFER QVREIEAKYD KKMKMLRDEL DLRRKTELHE VEERKNGQIH TLMQRHEEAF TDIKNYYNDI TLNNLALINS LKEQMEDMRK KEDHLEREMA EVSGQNKRLA DPLQKAREEM SEMQKQLANY ERDKQILLCT KARLKVREKE LKDLQWEHEV LEQRFTKVQQ ERDELYRKFT AAIQEVQQKT GFKNLVLERK LQALSAAVEK KEVQFNEVLA ASNLDPAALT LVSRKLEDVL ESKNSTIKDL QYELAQVCKA HNDLLRTYEA KLLAFGIPLD NVGFKPLETA VIGQTLGQGP AGLVGTPT

  • Molecular Weight

    56.3 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

GAS8, or G antigen of 8, is a member of the cancer/testis (CT) antigen family, which is primarily expressed in the germ cells of the testis and various malignancies, making it a candidate for cancer immunotherapy. Its expression in tumors but not in normal somatic tissues suggests a potential role in tumorigenesis, providing an opportunity for developing targeted therapies. The GAS8 protein has garnered attention due to its immunogenic properties, which can prompt strong immune responses in cancer patients. Research has focused on the characterization of GAS8, including its structure, function, and the mechanisms by which it may promote tumor growth or survival. This involves studying its expression patterns in different types of cancers, as well as its interactions with immune cells. Additionally, efforts are being made to explore the potential of GAS8 as a biomarker for cancer diagnosis and prognosis, as well as its viability as a target for vaccine development. Understanding the role of GAS8 in the tumor microenvironment and its implications in cancer therapy could provide insights into innovative approaches for treating malignancies, enhancing the specificity and efficacy of immune-mediated interventions. Overall, the research surrounding GAS8-recombinant protein aims to unlock its clinical potential and improve therapeutic strategies for cancer patients.

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