Analytical Data
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Gene name
NUDCD1
- Application
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Alternative Names
4921532K09Rik; AA407246; AW260430; AW556235; Chronic myelogenous leukemia tumor antigen 66; CML66; CML66 L; FLJ14991; NudC domain containing 1; NudC domain-containing protein 1; NUDC1_HUMAN; nudcd1; OVA66; RGD1310624; Tumor antigen CML66
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96RS6
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Expression Region
1-583 aa
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AA Sequence
MEVAANCSLR VKRPLLDPRF EGYKLSLEPL PCYQLELDAA VAEVKLRDDQ YTLEHMHAFG MYNYLHCDSW YQDSVYYIDT LGRIMNLTVM LDTALGKPRE VFRLPTDLTA CDNRLCASIH FSSSTWVTLS DGTGRLYVIG TGERGNSASE KWEIMFNEEL GDPFIIIHSI SLLNAEEHSI ATLLLRIEKE ELDMKGSGFY VSLEWVTISK KNQDNKKYEI IKRDILRGKS VPHYAAIEPD GNGLMIVSYK SLTFVQAGQD LEENMDEDIS EKIKEPLYYW QQTEDDLTVT IRLPEDSTKE DIQIQFLPDH INIVLKDHQF LEGKLYSSID HESSTWIIKE SNSLEISLIK KNEGLTWPEL VIGDKQGELI RDSAQCAAIA ERLMHLTSEE LNPNPDKEKP PCNAQELEEC DIFFEESSSL CRFDGNTLKT THVVNLGSNQ YLFSVIVDPK EMPCFCLRHD VDALLWQPHS SKQDDMWEHI ATFNALGYVQ ASKRDKKFFA CAPNYSYAAL CECLRRVFIY RQPAPMSTVL YNRKEGRQVG QVAKQQVASL ETNDPILGFQ ATNERLFVLT TKNLFLIKVN TEN
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Molecular Weight
66.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NUDCD1, or nucleolar and coiled-body phosphoprotein 1, is a multifunctional protein that plays a critical role in various cellular processes, including ribosome biogenesis, cell proliferation, and stress response. Recent studies have highlighted its involvement in the regulation of gene expression and cellular signaling pathways, particularly in the context of cancer and other diseases. The reorganization and function of nucleoli, where NUDCD1 is predominantly localized, are crucial for efficient ribosome production and cellular homeostasis. Abnormal expression or dysfunction of NUDCD1 has been associated with various malignancies, suggesting that it may serve as a potential biomarker for cancer diagnosis and prognosis. Given its pivotal role in cell growth and stress response, researchers are increasingly focusing on the biochemical pathways mediated by NUDCD1, exploring its interactions with other proteins and its post-translational modifications. The recombinant expression of NUDCD1 offers a valuable tool for elucidating its structure-function relationship, enabling in-depth investigations into its roles in cellular physiology and pathophysiology. Understanding the mechanisms underlying NUDCD1's activity could pave the way for novel therapeutic strategies targeting diseases linked to its dysregulation.
