Analytical Data
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基因名
NUCKS1
- Application
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别名
FLJ21480; FLJ32016; FLJ38536; JC7; NUCKS 1; NUCKS; NUCKS_HUMAN; Nucks1; Nuclear casein kinase and cyclin dependent kinase substrate 1; Nuclear ubiquitous casein and cyclin dependent kinases substrate; Nuclear ubiquitous casein and cyclin-dependent kinases substrate; Nuclear ubiquitous casein kinase and cyclin dependent kinase substrate; P1; Potential LAG1 interactor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H1E3
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表达区间
1-243 aa
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氨基酸序列
MSRPVRNRKV VDYSQFQESD DADEDYGRDS GPPTKKIRSS PREAKNKRRS GKNSQEDSED SEDKDVKTKK DDSHSAEDSE DEKEDHKNVR QQRQAASKAA SKQREMLMED VGSEEEQEEE DEAPFQEKDS GSDEDFLMED DDDSDYGSSK KKNKKMVKKS KPERKEKKMP KPRLKATVTP SPVKGKGKVG RPTASKASKE KTPSPKEEDE EPESPPEKKT STSPPPEKSG DEGSEDEAPS GED
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分子量
27.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NUCKS1 (Nuclear Kinesin-Like Protein 1) is a nucleolar protein that plays a crucial role in various cellular processes, including RNA metabolism, DNA repair, and ribosome biogenesis. Recent studies have highlighted its significance in the regulation of cell cycle and apoptosis, suggesting that NUCKS1 may be involved in tumorigenesis and cancer progression. Given its pivotal roles in cellular functions, researchers have increasingly focused on characterizing the NUCKS1 protein, particularly its structure and functional domains, to understand its mechanisms of action. The recombinant expression of NUCKS1 provides a valuable tool for these studies, allowing scientists to produce the protein in a controlled environment for biochemical assays and structural analyses. Such research is critical in elucidating the specific pathways involving NUCKS1, which may lead to novel therapeutic strategies for diseases where its function is disrupted, especially in cancer. Moreover, exploring the interactions between NUCKS1 and other cellular molecules can provide insights into its roles in maintaining cellular homeostasis and response to stress, which are essential aspects of cellular health and disease. As the understanding of NUCKS1 continues to evolve, it opens up new avenues for targeted therapies and biomarker developments in oncology and beyond.
