Analytical Data
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Gene name
NUCKS1
- Application
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Alternative Names
FLJ21480; FLJ32016; FLJ38536; JC7; NUCKS 1; NUCKS; NUCKS_HUMAN; Nucks1; Nuclear casein kinase and cyclin dependent kinase substrate 1; Nuclear ubiquitous casein and cyclin dependent kinases substrate; Nuclear ubiquitous casein and cyclin-dependent kinases substrate; Nuclear ubiquitous casein kinase and cyclin dependent kinase substrate; P1; Potential LAG1 interactor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H1E3
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Expression Region
1-243 aa
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AA Sequence
MSRPVRNRKV VDYSQFQESD DADEDYGRDS GPPTKKIRSS PREAKNKRRS GKNSQEDSED SEDKDVKTKK DDSHSAEDSE DEKEDHKNVR QQRQAASKAA SKQREMLMED VGSEEEQEEE DEAPFQEKDS GSDEDFLMED DDDSDYGSSK KKNKKMVKKS KPERKEKKMP KPRLKATVTP SPVKGKGKVG RPTASKASKE KTPSPKEEDE EPESPPEKKT STSPPPEKSG DEGSEDEAPS GED
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Molecular Weight
27.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NUCKS1 (Nuclear Kinesin-Like Protein 1) is a nucleolar protein that plays a crucial role in various cellular processes, including RNA metabolism, DNA repair, and ribosome biogenesis. Recent studies have highlighted its significance in the regulation of cell cycle and apoptosis, suggesting that NUCKS1 may be involved in tumorigenesis and cancer progression. Given its pivotal roles in cellular functions, researchers have increasingly focused on characterizing the NUCKS1 protein, particularly its structure and functional domains, to understand its mechanisms of action. The recombinant expression of NUCKS1 provides a valuable tool for these studies, allowing scientists to produce the protein in a controlled environment for biochemical assays and structural analyses. Such research is critical in elucidating the specific pathways involving NUCKS1, which may lead to novel therapeutic strategies for diseases where its function is disrupted, especially in cancer. Moreover, exploring the interactions between NUCKS1 and other cellular molecules can provide insights into its roles in maintaining cellular homeostasis and response to stress, which are essential aspects of cellular health and disease. As the understanding of NUCKS1 continues to evolve, it opens up new avenues for targeted therapies and biomarker developments in oncology and beyond.
