Analytical Data
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基因名
AP1m2
- Application
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别名
AP1m2；AP-1 complex subunit mu-2
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种属
Mouse
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9WVP1
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表达区间
1-423aa
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氨基酸序列
MSASAVFILD VKGKPLISRN YKGDVPMTEI DHFMPLLMQR EEEGVLAPLL SHGRVHFLWI KHSNLYLVAT TLKNANASLV YSFLYKTVEV FCEYFKELEE ESIRDNFVIV YDLLDELMDF GFPQTTDSKI LQEYITQQGN KLETGKSRVP PTVTNAVSWR SEGIKYKKNE VFIDVIESVN LLVNANGSVL LSEIVGTIKL KVFLSGMPEL RLGLNDRVLF ELTGRSKNKS VELEDVKFHQ CVRLSRFDND RTISFIPPDG DFELMSYRLS TQVKPLIWIE SVIEKFSHSR VEIMVKAKGQ FKKQSVANGV EISVPVPSDA DSPRFKTSVG SAKYVPEKNV VIWSIKSFPG GKEYLMRAHF GLPSVETEEV EGRPPIGVKF EIPYFTVSGI QVRYMKIIEK SGYQALPWVR YITQSGDYQL RTS
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分子量
48.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AP1M2, or AP180/clathrin-AP180-motif adaptin 2, is a protein that plays a crucial role in the endocytic pathway by facilitating the formation of clathrin-coated vesicles. These vesicles are essential for the internalization of various membrane proteins and lipids, contributing to cellular communication and nutrient uptake. The study of AP1M2 has gained prominence due to its potential implications in understanding the mechanisms underlying synaptic function and neurodegenerative diseases. Aberrant endocytosis has been linked to conditions such as Alzheimer's disease, highlighting the importance of proteins like AP1M2 in maintaining cellular homeostasis. Furthermore, the characterization of AP1M2's structure and functional domains can provide insights into its interactions with other endocytic proteins, potentially unveiling novel therapeutic targets. Recent research leveraging advanced techniques such as cryo-electron microscopy and mutagenesis studies aims to elucidate the precise molecular mechanisms by which AP1M2 operates. Understanding the intricate dynamics of AP1M2 may not only deepen our knowledge of cellular processes but also pave the way for innovative strategies in treating disorders associated with dysfunctional endocytosis. Overall, the investigation of AP1M2 represents a promising frontier in cell biology, with far-reaching implications for biomedical research and therapeutic development.
