Analytical Data
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基因名
RRAS
- Application
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别名
RRAS;Ras-related Protein R-Ras
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P10301
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表达区间
1-215aa
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氨基酸序列
MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI QSYFVSDYDP TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA GHGFLLVFAI NDRQSFNEVG KLFTQILRVK DRDDFPVVLV GNKADLESQR QVPRSEASAF GASHHVAYFE ASAKLRLNVD EAFEQLVRAV RKYQEQELPP SPPSAPRKKG GGCPC
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on RRAS (Regulator of Ras) recombinant protein has gained significant attention due to its crucial role in cellular signaling pathways and cancer biology. RRAS is a member of the Ras superfamily of small GTPases, which are pivotal regulators of various cellular functions such as growth, differentiation, and survival. Mutations in RRAS have been implicated in several malignancies, highlighting its potential as a therapeutic target. Moreover, the ability of RRAS to interact with multiple downstream effectors affects pathways like the MAPK and PI3K/Akt signaling cascades, which are integral to tumor development and progression. The production of RRAS recombinant protein allows for detailed studies of its biochemical properties and interactions, facilitating the exploration of its role in oncogenesis. Understanding RRAS function at a molecular level can provide insights into novel cancer treatment strategies, making it a promising candidate for drug development. Furthermore, the optimization of protocols for the expression and purification of RRAS may contribute to the advancement of therapeutic interventions aimed at modulating its activity in disease contexts. Overall, research into RRAS recombinant protein serves as a vital interdisciplinary effort bridging molecular biology, cancer research, and therapeutic innovation.
