Analytical Data
-
Gene name
NICN1
- Application
-
Alternative Names
NICN1; Nicolin-1; NPCEDRG; Tubulin polyglutamylase complex subunit 5; PGs5
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9BSH3
-
Expression Region
1-213 aa
-
AA Sequence
MSRVLVPCHV KGSVALQVGD VRTSQGRPGV LVIDVTFPSV APFELQEITF KNYYTAFLSI RVRQYTSAHT PAKWVTCLRD YCLMPDPHSE EGAQEYVSLF KHQMLCDMAR ISELRLILRQ PSPLWLSFTV EELQIYQQGP KSPSVTFPKW LSHPVPCEQP ALLREGLPDP SRVSSEVQQM WALTEMIRAS HTSARIGRFD VDGCYDLNLL SYT
-
Molecular Weight
24.2 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NICN1 (Nicotinic Acetylcholine Receptor Nicotinic Alpha-Subunit 1) is a protein of significant interest due to its role in the nervous system and potential implications in neurodevelopmental disorders and neurodegenerative diseases. The NICN1 gene encodes a subunit of nicotinic acetylcholine receptors (nAChRs), which are crucial for synaptic transmission and play a vital role in cognitive functions such as learning and memory. Dysregulation of nAChRs, including NICN1, has been implicated in various pathologies, including Alzheimer's disease, schizophrenia, and major depressive disorder. Given its involvement in these critical processes, researchers are focusing on the structural and functional characterization of NICN1 recombinant proteins to better understand their biophysical properties, interaction with ligands, and subsequent signaling pathways. The recombinant expression of NICN1 can enhance our understanding of its functional mechanisms and provide a platform for drug discovery aimed at modulating nAChR activity. Understanding the biochemistry and pharmacology of NICN1 can lead to novel therapeutic strategies for addressing cognitive deficits and restoring normal neuronal function in these debilitating conditions. As such, the study of NICN1 recombinant proteins represents a promising avenue for advancing our knowledge of neurobiology and developing targeted interventions for affected patients.
