Analytical Data
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Gene name
EPB49
- Application
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Alternative Names
EPB49；DMT；EPB49；Dematin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q08495
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Expression Region
1-405aa
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AA Sequence
MERLQKQPLT SPGSVSPSRD SSVPGSPSSI VAKMDNQVLG YKDLAAIPKD KAILDIERPD LMIYEPHFTY SLLEHVELPR SRERSLSPKS TSPPPSPEVW ADSRSPGIIS QASAPRTTGT PRTSLPHFHH PETSRPDSNI YKKPPIYKQR ESVGGSPQTK HLIEDLIIES SKFPAAQPPD PNQPAKIETD YWPCPPSLAV VETEWRKRKA SRRGAEEEEE EEDDDSGEEM KALRERQREE LSKVTSNLGK MILKEEMEKS LPIRRKTRSL PDRTPFHTSL HQGTSKSSSL PAYGRTTLSR LQSTEFSPSG SETGSPGLQN GEGQRGRMDR GNSLPCVLEQ KIYPYEMLVV TNKGRTKLPP GVDRMRLERH LSAEDFSRVF AMSPEEFGKL ALWKRNELKK KASLF
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Molecular Weight
45.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EPB49, also known as erythroid protein band 49, is a member of the spectrin superfamily and plays a critical role in maintaining the integrity and stability of the erythrocyte membrane. This protein is essential for the proper functioning of red blood cells, influencing their shape, flexibility, and longevity. Research into EPB49 has gained momentum due to its potential implications in various hematological disorders and diseases associated with altered erythrocyte properties, such as hereditary spherocytosis and certain types of anemia. Additionally, the exploration of EPB49 can enhance our understanding of the molecular mechanisms underlying red blood cell pathology and may uncover new therapeutic targets for these conditions. Advances in molecular biology techniques have facilitated detailed investigations into the gene encoding EPB49, its expression patterns, and the consequences of genetic mutations. By elucidating the role of EPB49 in erythropoiesis and red blood cell function, researchers aim to connect its biochemical properties with clinical manifestations, potentially guiding the development of innovative treatments for blood-related disorders. Such studies not only contribute to basic biomedical knowledge but also hold promise for translational applications in regenerative medicine and blood transfusion safety, reflecting the importance of EPB49 in both clinical and research contexts.
