Analytical Data
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Gene name
RGS14
- Application
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Alternative Names
RGS14;Regulator of G-Protein signaling 14
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43566
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Expression Region
1-566aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MPGKPKHLGV PNGRMVLAVS DGELSSTTGP QGQGEGRGSS LSIHSLPSGP SSPFPTEEQP VASWALSFER LLQDPLGLAY FTEFLKKEFS AENVTFWKAC ERFQQIPASD TQQLAQEARN IYQEFLSSQA LSPVNIDRQA WLGEEVLAEP RPDMFRAQQL QIFNLMKFDS YARFVKSPLY RECLLAEAEG RPLREPGSSR LGSPDATRKK PKLKPGKSLP LGVEELGQLP PVEGPGGRPL RKSFRRELGG TANAALRRES QGSLNSSASL DLGFLAFVSS KSESHRKSLG STEGESESRP GKYCCVYLPD GTASLALARP GLTIRDMLAG ICEKRGLSLP DIKVYLVGNE QALVLDQDCT VLADQEVRLE NRITFELELT ALERVVRISA KPTKRLQEAL QPILEKHGLS PLEVVLHRPG EKQPLDLGKL VSSVAAQRLV LDTLPGVKIS KARDKSPCRS QGCPPRTQDK ATHPPPASPS SLVKVPSSAT GKRQTCDIEG LVELLNRVQS SGAHDQRGLL RKEDLVLPEF LQLPAQGPSS EETPPQTKSA AQPIGGSLNS TTDSAL
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Molecular Weight
64 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RGS14 (Regulator of G protein signaling 14) is a unique member of the RGS protein family, known for its multifunctionality in cellular signaling. It plays a critical role in the regulation of G protein-coupled receptor (GPCR) signaling pathways, which are pivotal in various physiological processes including cell growth, differentiation, and hormonal responses. RGS14 is characterized by its ability to interact with multiple signaling components, including G proteins and other regulatory proteins, thereby influencing the duration and intensity of signals transduced by GPCRs. Moreover, it harbors a specialized GoLoco motif that enhances its interactions with GDP-bound G proteins, further modulating signal transduction. Recent studies have indicated that aberrations in RGS14 expression and function are implicated in a range of pathological conditions, including cancer and neurodegenerative diseases. The investigation of RGS14 as a recombinant protein has gained attention as it facilitates the elucidation of its functional roles and mechanisms of action under controlled experimental conditions. This approach assists in identifying potential therapeutic targets and developing pharmacological agents aimed at modulating RGS14 activity to restore normal signaling pathways disrupted in disease states. Understanding the intricate dynamics of RGS14 in cellular contexts may ultimately provide insights into novel strategies for disease intervention and treatment.
