Analytical Data
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Gene name
RGS1
- Application
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Alternative Names
RGS1;1R20;BL34;IER1;Regulator of G-Protein signaling 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q08116
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Expression Region
1-209aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMRAAAI STPKLDKMPG MFFSANPKEL KGTTHSLLDD KMQKRRPKTF GMDMKAYLRS MIPHLESGMK SSKSKDVLSA AEVMQWSQSL EKLLANQTGQ NVFGSFLKSE FSEENIEFWL ACEDYKKTES DLLPCKAEEI YKAFVHSDAA KQINIDFRTR ESTAKKIKAP TPTCFDEAQK VIYTLMEKDS YPRFLKSDIY LNLLNDLQAN SLK
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS1 (Regulator of G-protein Signaling 1) is a crucial adaptor protein that plays a significant role in modulating G-protein-coupled receptor (GPCR) signaling pathways, which are essential for various physiological processes including immune responses and cell growth. Research into RGS1 has gained prominence due to its implications in diverse biological functions and potential therapeutic applications. This protein serves as a GTPase-activating protein, accelerating the hydrolysis of GTP bound to Gα subunits, thus terminating the signaling cascade initiated by GPCR activation. Abnormal expression or activity of RGS1 has been linked to several diseases, including cancer, autoimmune disorders, and cardiovascular conditions, making it a target of interest for drug discovery. Additionally, RGS1 is known to interact with various cellular partners, influencing downstream signaling pathways and cellular responses. Understanding the structure and function of RGS1, along with the development of recombinant forms of the protein, is critical for elucidating its role in health and disease. The generation of recombinant RGS1 protein allows researchers to study its biochemical properties, interaction networks, and functional dynamics in a controlled environment, facilitating the identification of potential therapeutic interventions that could modify its activity. As such, exploring the biochemistry and pharmacology of RGS1 represents a vital area of research with the potential to unlock novel strategies for treating diseases linked to dysregulated GPCR signaling.
