Analytical Data
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Gene name
DNS
- Application
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Alternative Names
DNS；DNASE2A；DNL2；Deoxyribonuclease-2-alpha
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00115
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Expression Region
19-360aa
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AA Sequence
CY GDSGQPVDWF VVYKLPALRG SGEAAQRGLQ YKYLDESSGG WRDGRALINS PEGAVGRSLQ PLYRSNTSQL AFLLYNDQPP QPSKAQDSSM RGHTKGVLLL DHDGGFWLVH SVPNFPPPAS SAAYSWPHSA CTYGQTLLCV SFPFAQFSKM GKQLTYTYPW VYNYQLEGIF AQEFPDLENV VKGHHVSQEP WNSSITLTSQ AGAVFQSFAK FSKFGDDLYS GWLAAALGTN LQVQFWHKTV GILPSNCSDI WQVLNVNQIA FPGPAGPSFN STEDHSKWCV SPKGPWTCVG DMNRNQGEEQ RGGGTLCAQL PALWKAFQPL VKNYQPCNGM ARKPSRAYKI
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Molecular Weight
39.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of DNA recombination proteins (DRPs) has gained significant attention due to their crucial role in the maintenance of genomic integrity and the regulation of genetic diversity in various organisms. These proteins are essential for processes such as homologous recombination, DNA repair, and the accurate segregation of chromosomes during cell division. In eukaryotic cells, DRPs facilitate the exchange of genetic information between homologous DNA sequences, which is particularly important during meiosis for generating genetic variation. Recent advances in molecular biology and structural genomics have allowed researchers to elucidate the intricate mechanisms by which these proteins operate, including their dynamic interactions with DNA and other proteins. Furthermore, understanding the functional and structural diversity of DRPs across different species provides insights into evolutionary adaptations and the potential for developing biotechnological applications, such as gene editing and synthetic biology. The potential link between DRPs and various diseases, including cancer, is also a focal point of current research, as malfunctioning recombination processes can lead to genomic instability. Overall, the exploration of DNA recombination proteins is a burgeoning field that merges basic biological research with applied sciences, emphasizing the need for ongoing investigations into their mechanisms and implications.
