Analytical Data
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Gene name
MXD4
- Application
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Alternative Names
bHLHc12; Class C basic helix loop helix protein 12; Class C basic helix-loop-helix protein 12; MAD 4; MAD4; Mad4 homolog; MAD4_HUMAN; Max associated protein 4; MAX dimerization protein 4; Max dimerizer 4; Max interacting transcriptional repressor MAD4; Max-associated protein 4; Max-interacting transcriptional repressor MAD4; MST 149; MST149; MSTP 149; MSTP149; MXD 4; MXD4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14582
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Expression Region
1-209 aa
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AA Sequence
MELNSLLILL EAAEYLERRD REAEHGYASV LPFDGDFARE KTKAAGLVRK APNNRSSHNE LEKHRRAKLR LYLEQLKQLV PLGPDSTRHT TLSLLKRAKV HIKKLEEQDR RALSIKEQLQ QEHRFLKRRL EQLSVQSVER VRTDSTGSAV STDDSEQEVD IEGMEFGPGE LDSVGSSSDA DDHYSLQSGT GGDSGFGPHC RRLGRPALS
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Molecular Weight
23.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MXD4 (Max dimerization protein 4) is a member of the Myc family of transcription factors, known for its role in regulating gene expression and cellular processes such as proliferation, differentiation, and apoptosis. Research into MXD4 has gained traction due to its potential implications in cancer biology, particularly its function as a transcriptional repressor that can antagonize the activity of oncogenic Myc proteins. Elevated levels of Myc are commonly associated with various malignancies, making MXD4’s ability to modulate Myc signaling a point of interest for therapeutic intervention. Moreover, studies suggest that MXD4 could be involved in the regulatory networks influencing metabolic pathways and cellular stress responses, further highlighting its significance beyond cancer. Investigating MXD4 as a recombinant protein allows researchers to explore its structural and functional characteristics, paving the way for understanding its molecular mechanisms and interactions with other cellular components. The ability to produce MXD4 in a controlled laboratory setting facilitates detailed biochemical assays and potential drug development aimed at manipulating its activity. Current studies are focused on elucidating MXD4's precise role in cellular homeostasis and its potential as a biomarker for disease progression or therapeutic targets, thereby contributing to a broader understanding of cell biology and the development of strategies for cancer treatment.
