Analytical Data
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基因名
CASC5
- Application
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别名
CASC5；CASC5；KIAA1570；Kinetochore scaffold 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NG31
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表达区间
全长
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氨基酸序列
full
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分子量
265.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CASC5, also known as Cancer Susceptibility Candidate 5, is a crucial protein that plays a significant role in the process of mitosis, particularly in chromosomal alignment and segregation during cell division. The proper function of CASC5 is essential for maintaining genomic stability, and its dysregulation has been implicated in various cancers, where it may contribute to aneuploidy and tumorigenesis. Recent studies have highlighted its involvement in the formation and function of the mitotic spindle and its interactions with other proteins related to the cell cycle. Given the increasing incidence of cancer and the importance of understanding the molecular mechanisms underlying tumorigenesis, CASC5 has become a focal point for research in cancer biology. Investigating the structure and function of CASC5, particularly through the development of recombinant protein, is vital for elucidating its role in cell division and cancer progression. Furthermore, creating recombinant forms of CASC5 allows for the exploration of its biochemical properties, interaction networks, and potential as a therapeutic target. By mapping the pathways in which CASC5 is involved, researchers aim to identify novel strategies for cancer diagnosis and treatment, thus contributing significantly to the field of oncology and molecular medicine.
