Analytical Data
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Gene name
CASC5
- Application
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Alternative Names
CASC5；CASC5；KIAA1570；Kinetochore scaffold 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NG31
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Expression Region
全长
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AA Sequence
full
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Molecular Weight
265.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CASC5, also known as Cancer Susceptibility Candidate 5, is a crucial protein that plays a significant role in the process of mitosis, particularly in chromosomal alignment and segregation during cell division. The proper function of CASC5 is essential for maintaining genomic stability, and its dysregulation has been implicated in various cancers, where it may contribute to aneuploidy and tumorigenesis. Recent studies have highlighted its involvement in the formation and function of the mitotic spindle and its interactions with other proteins related to the cell cycle. Given the increasing incidence of cancer and the importance of understanding the molecular mechanisms underlying tumorigenesis, CASC5 has become a focal point for research in cancer biology. Investigating the structure and function of CASC5, particularly through the development of recombinant protein, is vital for elucidating its role in cell division and cancer progression. Furthermore, creating recombinant forms of CASC5 allows for the exploration of its biochemical properties, interaction networks, and potential as a therapeutic target. By mapping the pathways in which CASC5 is involved, researchers aim to identify novel strategies for cancer diagnosis and treatment, thus contributing significantly to the field of oncology and molecular medicine.
