Analytical Data
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基因名
CAPS2
- Application
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别名
CAPS2；CAPS2；KIAA1591；Calcium-dependent secretion activator 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BXY5
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表达区间
1-557aa
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氨基酸序列
MGNSFCYTAV YCMINTGTQM DLEVKGVAAT SRSQIQPFFG RKKPLQQRWT SESWTNQNSC PPVVPRLDLG SLVDSDDEDN FSYIPLSTAN LPNSSSTLGW VTPCQTPYTQ YHLNKLDQNI IPENLPAPTD KCKLKYQQCK TEIKEGYKQY SQRNAENTKS NVTHKQSPRN KIDEKCVQDE EANTDDLTTL DRKAILQQGY ADNSCDKQQR ARKLDAEIVA AEKKKQIVAE QVMIDHLSRA VISDPEQNLA IEQKESDHIL PDSKMTPLRF RKRTLHETKI RTHSTLTENV LSHKLQFDGR IVSRNGRDAC RELIGFFFTH DQSLTIYEYR QFGKNRTNVL PFIQKSIYSH QCGRRKGKQY RLGDFYVGAT LTFLSSDHLS LPESIKENTL LKLRITNIDQ IALDSLKTAS MEQEDDIIIQ ETNDRLVFKA IQDVLKEKLH KRGVRILTGL GKYFQQLDKE GNGLLDKADF KQALKVFHLE VSEKDFESAW LILNDNGNGK VDYGEFKRGI IGEMNEYRKS YVRKAFMKLD FNKSGSVPII NIRKCYCAKK HSQVISG
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分子量
61.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAPS2 (Ca2+-dependent Activator Protein for Secretion 2) is a neuronal protein that plays a critical role in calcium-mediated exocytosis, particularly in the release of neurotransmitters. It is part of the CAPS family, which interacts with synaptic vesicles and facilitates their fusion with the presynaptic membrane upon calcium influx. Research into CAPS2 has gained momentum due to its potential implications in neurological disorders, where alterations in neurotransmitter release can lead to various pathologies, including mood disorders and neurodegenerative diseases. Understanding the structure and function of CAPS2 at the molecular level can provide insights into its mechanistic role in synaptic transmission and potential pathways for therapeutic intervention. Moreover, the reconstitution of CAPS2 as a recombinant protein allows for detailed biochemical and biophysical studies, leading to the exploration of its interactions with other proteins and lipids in the synaptic environment. Investigations have revealed that CAPS2 is critical for the regulation of dense-core vesicle secretion and that its activity may be modulated by cellular signaling pathways involving calcium and phosphoinositides. As such, CAPS2 represents an important molecular target for deciphering the complexities of synaptic physiology and developing strategies for treating synaptic dysfunction. Continued research in this area can enhance our understanding of how synaptic mechanisms are disrupted in various neurological conditions, ultimately aiming to pave the way for developing innovative therapeutic approaches.
